Preventive and ameliorating effects of citrus D-limonene on dyslipidemia and hyperglycemia in mice with high-fat diet-induced obesity

被引:124
作者
Jing, Li [1 ,2 ]
Zhang, Yu [3 ]
Fan, Shengjie [3 ]
Gu, Ming [3 ]
Guan, Yu [3 ]
Lu, Xiong [4 ]
Huang, Cheng [3 ]
Zhou, Zhiqin [1 ,2 ]
机构
[1] Southwest Univ, Coll Hort & Landscape Architecture, Chongqing 400716, Peoples R China
[2] Minist Educ, Key Lab Hort Sci Southern Mt Reg, Chongqing 400715, Peoples R China
[3] Shanghai Univ Tradit Chinese Med, Sch Pharm, Drug Discovery Lab, Shanghai 201203, Peoples R China
[4] Shanghai Univ Tradit Chinese Med, Sci Expt Ctr, Shanghai 201203, Peoples R China
基金
中国国家自然科学基金;
关键词
D-limonene; Metabolic disorder; Dyslipidemia; Hyperglycemia; ESSENTIAL OIL; PPAR-GAMMA; INHIBITION; MANAGEMENT; REDUCTASE; HEALTH; ALPHA;
D O I
10.1016/j.ejphar.2013.06.022
中图分类号
R9 [药学];
学科分类号
100702 [药剂学];
摘要
D-limonene is a major constituent in citrus essential oil, which is used in various foods as a flavoring agent. Recently, D-limonene has been reported to alleviate fatty liver induced by a high-fat diet. Here we determined the preventive and therapeutic effects of D-limonene on metabolic disorders in mice with high-fat diet-induced obesity. In the preventive treatment, D-limonene decreased the size of white and brown adipocytes, lowered serum triglyceride (TG) and fasting blood glucose levels, and prevented liver lipid accumulations in high-fat diet-fed C5713L/6 mice. In the therapeutic treatment, D-limonene reduced serum TG, low-density lipoprotein cholesterol (LDL-c) and fasting blood glucose levels and glucose tolerance, and increased serum high-density lipoprotein cholesterol (HDL-c) in obese mice. Using a reporter assay and gene expression analysis, we found that D-limonene activated peroxisome proliferator-activated receptor (PPAR)-alpha signaling, and inhibited liver X receptor (LXR)-beta signaling. Our data suggest that the intake of D-limonene may benefit patients with dyslipidemia and hyperglycemia and is a potential dietaiy supplement for preventing and ameliorating metabolic disorders. (C) 2013 Elsevier RN. All rights reserved,
引用
收藏
页码:46 / 55
页数:10
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