Immunologic studies of specific mucosal and systemic immune responses in Mexican school children after booster aerosol or subcutaneous immunization with measles vaccine

被引：36

作者：

Bellanti, JA ^{[1
]}

Zeligs, BJ

Mendez-Inocencio, J

García-Garcia, MD

Islas-Romero, R

Omidvar, B

Omidvar, J

Kim, G

de Castro, JF

Amor, JS

Walls, L

Bellini, WJ

Valdespino-Gomez, JL

机构：

[1] Georgetown Univ, Med Ctr, Int Ctr Interdisciplinary Studies Immunol, Washington, DC 20007 USA

[2] Georgetown Univ, Med Ctr, Dept Pediat, Washington, DC 20007 USA

[3] Inst Nacl Salud Publ, Cuernavaca, Morelos, Mexico

[4] Ctr Dis Control & Prevent, Atlanta, GA USA

来源：

VACCINE | 2004年 / 22卷 / 9-10期

关键词：

mucosal and systemic immune responses; measles vaccine; school children;

D O I：

10.1016/j.vaccine.2003.09.032

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The purpose of the present study was to compare serum and mucosal immune responses following either aerosol (Aer) or subcutaneous (SQ) measles immunization of Mexican school children. A cohort of 49 children from 6 to 7 years of age received either Aer (n = 22) or SQ (n = 27) Edmonston-Zagreb (EZ) measles vaccine. Serum and nasal secretions were collected prior to (Pre), 1 and 3 months (mos) intervals and analyzed for immunoglobulin (Ig) concentrations and measles specific Ig isotype-associated antibody by enzyme immunoassay (EIA). Serum and nasal IgG and IgA antibody responses were stimulated following immunization with live, attenuated EZ measles vaccine administered either by SQ or Aer routes but these responses were significantly greater by the Aer compared to the SQ route. These studies also suggest that the level of antibody in these secretions may serve as an important marker of immunity to measles and lend further support for aerosol immunization as an effective alternative vaccine delivery strategy for measles eradication. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：1214 / 1220

页数：7

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