Cerebral ischemia in 5-lipoxygenase knockout mice

被引：41

作者：

Kitagawa, K

Matsumoto, M

Hori, M

机构：

[1] Osaka Univ, Grad Sch Med, Dept Internal Med & Therapeut A8, Div Strokol, Suita, Osaka 5650871, Japan

[2] Hiroshima Univ, Grad Sch Biomed Sci, Dept Clin Neurosci & Therapeut, Hiroshima, Japan

来源：

BRAIN RESEARCH | 2004年 / 1004卷 / 1-2期

关键词：

cerebral ischemia; 5-lipoxygenase; knockout mouse; leukotriene;

D O I：

10.1016/j.brainres.2004.01.018

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cerebral ischemia induces 5-lipoxygenase translocation and leukotriene production in the brain. We tried to clarify the pathological significance of 5-lipoxygenase on cerebral ischemia using 5-lipoxygenase knockout mice. No significant difference was observed in the infarct size following permanent and transient ischemia for 60 min between both types of mice. The present study did not support the idea that leukotriene production is involved in infarct expansion in focal cerebral ischemia. (C) 2004 Elsevier B.V. All rights reserved.

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收藏

页码：198 / 202

页数：5

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