The Mediterranean diet improves the systemic lipid and DNA oxidative damage in metabolic syndrome individuals. A randomized, controlled, trial

被引：150

作者：

Teresa Mitjavila, Maria ^{[1
]}

Fandos, Marta ^{[2
]}

Salas-Salvado, Jordi ^{[3
,4
]}

Covas, Maria-Isabel ^{[5
]}

Borrego, Silvia ^{[2
]}

Estruch, Ramon ^{[6
]}

Lamuela-Raventos, Rosa ^{[7
]}

Corella, Dolores ^{[8
]}

Angel Martinez-Gonzalez, Miguel ^{[9
]}

Sanchez, Julia M. ^{[2
]}

Bullo, Monica ^{[3
,4
]}

Fito, Montserrat ^{[8
]}

Tormos, Carmen ^{[2
]}

Cerda, Concha ^{[10
]}

Casillas, Rosario ^{[1
]}

Jose Moreno, Juan ^{[1
]}

Iradi, Antonio ^{[11
]}

Zaragoza, Cristobal ^{[2
]}

Chaves, Javier ^{[12
]}

Saez, Guillermo T. ^{[2
,10
]}

机构：

[1] Univ Barcelona, Dept Physiol, INSA, E-08007 Barcelona, Spain

[2] Univ Valencia, Dept Biochem & Mol Biol, Fac Med, INCLIVA, Valencia 46010, Spain

[3] Univ Rovira & Virgili, Human Nutr Unit, IISPV, E-43201 Reus, Spain

[4] Univ Rovira & Virgili, CIBER Physiopathol Obes & Nutr CIBEROBN, E-43201 Reus, Spain

[5] IMIM Inst Recerca Hosp del Mar, Cardiovasc Risk & Nutr Res Grp, CIBER Physiopathol Obes & Nutr CIBEROBN, Barcelona, Spain

[6] Univ Barcelona, Dept Internal Med, IDIBABS, Hosp Clin, E-08007 Barcelona, Spain

[7] Univ Barcelona, Nutr & Food Sci Dept XaRTA, INSA, E-08007 Barcelona, Spain

[8] Univ Valencia, Dept Prevent Med, Valencia 46010, Spain

[9] Univ Navarra, Dept Prevent Med & Publ Hlth, E-31080 Pamplona, Spain

[10] CDB Gen Univ Hosp, Serv Clin Anal, Valencia, Spain

[11] Univ Valencia, Dept Physiol, Fac Med, Valencia 46010, Spain

[12] Valencia Clin Hosp Res Fdn INCLIVA, Lab Genet Studies, Valencia, Spain

来源：

CLINICAL NUTRITION | 2013年 / 32卷 / 02期

关键词：

Mediterranean diet; Oxidative stress; Metabolic syndrome; DNA damage; F2-isoprostanes; PREDIMED; OLIVE OILS; PHENOLIC-COMPOUNDS; OXIDIZED LDL; STRESS; METAANALYSIS; PREVALENCE; NUTRITION; ADHERENCE; HUMANS; PLASMA;

D O I：

10.1016/j.clnu.2012.08.002

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Background Ea aims: Metabolic syndrome (MetS), in which a non-classic feature is an increase in systemic oxidative biomarkers, presents a high risk of diabetes and cardiovascular disease (CVD). Adherence to the Mediterranean Diet (MedDiet) is associated with a reduced risk of MetS. However, the effect of the MedDiet on biomarkers for oxidative damage has not been assessed in MetS individuals. We have investigated the effect of the MedDiet on systemic oxidative biomarkers in MetS individuals. Methods: Randomized, controlled, parallel clinical trial in which 110 female With MetS, aged 55-80, were recruited into a large trial (PREDIMED Study) to test the efficacy of the traditional MedDiet on the primary prevention of CVD. Participants were assigned to a low-fat diet or two traditional MedDiets (MedDiet + virgin olive oil or MedDiet + nuts). Both MedDiet group participants received nutritional education and either free extra virgin olive oil for all the family (1 L/week), or free nuts (30 g/day). Diets were ad libitum. Changes in urine levels of F2-lsoprostane (F2-IP) and the DNA damage base 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dG) were evaluated at 1-year trial. Results: After 1-year urinary F2-IP decreased in all groups, the decrease in MedDiet groups reaching a borderline significance versus that of the Control group. Urinary 8-oxo-dG was also reduced in all groups, with a higher decrease in both MedDiet groups versus the Control one (P < 0.001). Conclusions: MedDiet reduces oxidative damage to lipids and DNA in MetS individuals. Data from this study provide evidence to recommend the traditional MedDiet as a useful tool in the MetS management. Registered under Clinical Trials.gov Identifier no. NCT00123456. (C) 2012 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.

引用

页码：172 / 178

页数：7

共 44 条

[1]

Coronary atherosclerosis and somatic mutations: an overview of the contributive factors for oxidative DNA damage [J].