Synthesis and biological evaluation of phosphonated carbocyclic 2-oxa-3′-aza-nucleosides

被引：36

作者：

Chiacchio, U

Iannazzo, D

Piperno, A

Romeo, R

Romeo, G

Rescifina, A

Saglimbeni, M

机构：

[1] Univ Messina, Dipartimento Farmacochim, I-98168 Messina, Italy

[2] Univ Catania, Dipartimento Sci Chim, I-95125 Catania, Italy

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 04期

关键词：

modified nucleosides; 1,3-dipolar cycloaddition; antiviral activity; phosphonated nucleosides;

D O I：

10.1016/j.bmc.2005.09.024

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of carbocyclic 2'-oxa-3'-aza-nucleosides has been described, based on the 1,3-dipolar cycloaddition of a new phosphonated nitrone with vinyl acetate followed by coupling with silylated nucleobases. The obtained compounds have been evaluated for their ability to inhibit the reverse transcriptase of avian myeloblastosis retrovirus: no significant activity has been observed. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：955 / 959

页数：5

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