Oral precancerous and malignant lesions associated with graft-versus-host disease: Report of 2 cases

被引:36
作者
Abdelsayed, RA
Sumner, T
Allen, CM
Treadway, A
Ness, GM
Penza, SL
机构
[1] Med Coll Georgia, Sch Dent, Augusta, GA 30912 USA
[2] Ohio State Univ, Coll Med & Publ Hlth, Dept Internal Med, Div Hematol Oncol, Columbus, OH 43210 USA
[3] Ohio State Univ, Coll Dent, Columbus, OH 43210 USA
[4] Med Coll Georgia, Augusta, GA 30912 USA
来源
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTICS | 2002年 / 93卷 / 01期
关键词
D O I
10.1067/moe.2002.119736
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
The development of secondary malignancies has been recognized as a potential iatrogenic complication in patients who have graft-versus-host disease secondary to bone marrow transplantation. Lymphohematopoietic cancer is most frequent, although solid malignancies have also been reported. We describe 2 patients with graft-versus-host disease who developed oral precancerous and malignant lesions. The first patient, a 24-year-old white man, had erythroplakia of the buccal mucosa that proved to be carcinoma in situ histopathologically. The second patient, a 14-year-old Hispanic boy, developed synchronous cutaneous and lingual squamous cell carcinomas. The current cases and similar sporadic case reports found in the literature highlight the susceptibility of patients with graft-versus-host disease to the development of oral cancer. Therefore, it is recommended that thorough evaluation of the oral mucosa and close follow-up be offered to all patients treated with bone marrow transplantation and particularly to those who develop graft-versus-host disease.
引用
收藏
页码:75 / 80
页数:6
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