Clinical significance of inflammatory and fibrogenic cytokines in diabetic nephropathy

被引：80

作者：

El Mesallamy, Hala O. ^{[2
]}

Ahmed, Hanaa H. ^{[1
]}

Bassyouni, Atef A. ^{[3
]}

Ahmed, Amira S. ^{[1
]}

机构：

[1] Natl Res Ctr, Hormone Dept, Cairo, Egypt

[2] Ain Shams Univ, Fac Pharm, Dept Biochem, Cairo, Egypt

[3] Natl Inst Diabet & Endocrinol, Dept Internal Med, Cairo, Egypt

来源：

CLINICAL BIOCHEMISTRY | 2012年 / 45卷 / 09期

关键词：

Inflammatory chemokine; Fibrogenic markers; Diabetic nephropathy; Microalbuminuria; Macroalbuminuria; TISSUE-GROWTH-FACTOR; MONOCYTE CHEMOATTRACTANT PROTEIN-1; TGF-BETA; MESANGIAL CELLS; FACTOR CTGF; EXPRESSION; DISEASE; INJURY; PROGRESSION; TGF-BETA-1;

D O I：

10.1016/j.clinbiochem.2012.02.021

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Objectives: To study the role of inflammatory chemokine: monocyte chemoattractant protein-1 (MCP-1), and fibrogenic markers [transforming growth factor beta-1 (TGF-beta(1)), connective tissue growth factor (CTGF) and fibronectin (FN)] in diabetic nephropathy (DN). Design and methods: This study included 17 control and 65 type 2 diabetic subjects (18 normoalbuminuric, 22 microalbuminuric and 25 macroalbuminuric). Demographic characteristics, diabetic index and kidney function tests were monitored. Serum TGF-beta(1), plasma CTGF, MCP-1 and FN levels were assayed. Results: Microalbuminuric and macroalbuminuric subjects showed a significant elevation in TGF-beta(1), CTGF, MCP-1 and FN levels as compared with control and normoalbuminuric subjects. There was positive correlation between these markers and fasting plasma glucose, albumin excretion rate and with each other. Conclusion: This study revealed the importance of these markers in DN pathogenesis which is powered by their association and thus the possibility of their use as biochemical markers in DN was suggested. (C) 2012 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

引用

页码：646 / 650

页数：5

共 37 条

[1] TGF-β1 stimulates monocyte chemoattractant protein-1 expression in mesangial cells through a phosphodiesterase isoenzyme 4-dependent process [J].