Blastic NK-cell lymphoma/leukemia with T-cell receptor γ rearrangement

被引：18

作者：

Aoyama, Y

Yamane, T

Hino, M

Ohta, K

Nakamae, H

Yamamura, R

Koh, KR

Takubo, T

Inoue, T

Tatsumi, Y

Tatsumi, N

机构：

[1] Osaka City Univ, Sch Med, Dept Clin Hematol, Abeno Ku, Osaka 5458586, Japan

[2] Osaka City Gen Hosp, Dept Pathol, Abeno Ku, Osaka 5458586, Japan

来源：

ANNALS OF HEMATOLOGY | 2001年 / 80卷 / 12期

关键词：

blastic NK-cell lymphoma/leukemia; CD4; CD56; T-cell receptor gamma rearrangement;

D O I：

10.1007/s00277-001-0380-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 79-year-old Japanese man was admitted to our hospital with dyspnea in June 1999. Physical examination revealed general exanthema, hepatosplenomegaly, and lymphadenopathy. Increased numbers of abnormal cells were observed in peripheral blood; these cells were of lymphoblastic morphology with high nuclear/cytoplasm ratios and few azurophilic granules. Immunophenotypic analysis revealed positivity for CD2, CD4, CD56, and HLA-DR, and negativity for CD3, CD13, CD16, CD33, CD34, and T cell receptor (TCR). On genotypic analysis, TCRgamma chain was rearranged, but neither the TCRP chain nor TCRdelta chain. Despite an initial good response to chemotherapy the disease relapsed in the early stage, and the patient died 6 months after diagnosis.

引用

页码：752 / 754

页数：3

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