Communication between gastrointestinal bacteria and the nervous system

被引：235

作者：

Bravo, Javier A. ^{[1
]}

Julio-Pieper, Marcela ^{[1
]}

Forsythe, Paul ^{[2
,3
]}

Kunze, Wolfgang ^{[4
]}

Dinan, Timothy G. ^{[6
,8
]}

Bienenstock, John ^{[2
,5
]}

Cryan, John F. ^{[7
,8
]}

机构：

[1] Pontificia Univ Catolica Valparaiso, Fac Ciencias, Inst Quim, Valparaiso, Chile

[2] St Josephs Healthcare, McMaster Brain Body Inst, Hamilton, ON, Canada

[3] McMaster Univ, Dept Med, Hamilton, ON, Canada

[4] McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON, Canada

[5] Dept Pathol & Mol Med, Hamilton, ON, Canada

[6] Natl Univ Ireland Univ Coll Cork, Dept Psychiat, Cork, Ireland

[7] Natl Univ Ireland Univ Coll Cork, Dept Anat & Neurosci, Cork, Ireland

[8] Natl Univ Ireland Univ Coll Cork, Lab NeuroGastroenterol, Alimentary Pharmabiot Ctr, Cork, Ireland

来源：

CURRENT OPINION IN PHARMACOLOGY | 2012年 / 12卷 / 06期

关键词：

IRRITABLE-BOWEL-SYNDROME; ANXIETY-LIKE BEHAVIOR; LACTOBACILLUS-REUTERI; GERM-FREE; MATERNAL SEPARATION; BIFIDOBACTERIUM; MICROBIOTA; PROBIOTICS; INFECTION; FLORA;

D O I：

10.1016/j.coph.2012.09.010

中图分类号：

R9 [药学];

学科分类号：

100702 [药剂学];

摘要：

In the past few years, intestinal microbiota has emerged as a novel target for the treatment of gut-brain axis alterations. These include functional gastrointestinal disorders, such as irritable bowel syndrome (IBS), which can be comorbid with stress-related psychiatric conditions. Thus, modulation of the microbiota (e.g. with the use of probiotics) could be proposed as a novel strategy not only for the treatment of IBS but also as an adjuvant for psychiatric treatment of anxiety and depression.

引用

页码：667 / 672

页数：6

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