Central nociceptive role of prostacyclin (IP) receptor induced by peripheral inflammation

被引：46

作者：

Doi, Y

Minami, T

Nishizawa, M

Mabuchi, T

Mori, H

Ito, S ^{[1
]}

机构：

[1] Osaka Med Coll, Dept Anesthesiol, Takatsuki, Osaka 5698686, Japan

[2] Kansai Med Univ, Dept Med Chem, Moriguchi, Osaka 5708506, Japan

来源：

NEUROREPORT | 2002年 / 13卷 / 01期

关键词：

carrageenan; cyclooxygenase; hyperalgesia; prostacyclin (PGI(2)); prostacyclin (IP) receptor; prostaglandin I synthase; mRNA; spinal cord;

D O I：

10.1097/00001756-200201210-00022

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Prostacyclin (PGI(2)) is well known to play crucial roles in induction of edema and pain behavior in the periphery. In the present study, we investigated the central role of PGI(2) in inflammatory pain. Intraplantar injection of carrageenan markedly induced the expression of prostacyclin receptor (IP receptor) mRNA with the maximum at 6 h, coincidently induction of the inducible form of cyclooxygenase (COX-2), although IP receptor mRNA was weakly expressed in the spinal cord of naive mice. Intrathecal administration of the IP agonist cicaprost induced mechanical hyperalgesia 6 h after carrageenan injection. These results suggest that PGI(2) is involved in pain transmission at the spinal cord following expression of IP receptor mRNA induced by peripheral inflammation. NeuroReport 13:93-96 (C) 2002 Lippincott Williams Wilkins.

引用

页码：93 / 96

页数：4

共 20 条

[1]

Aley KO, 1999, J NEUROSCI, V19, P2181

[2] The role of IP prostanoid receptors in inflammatory pain [J].