Induction of apoptosis in HL-60 cells by eicosapentaenoic acid (EPA) is associated with downregulation of bcl-2 expression

被引：51

作者：

Chiu, LCM ^{[1
]}

Wan, JMF ^{[1
]}

机构：

[1] Univ Hong Kong, Dept Zool, Hong Kong SAR, Peoples R China

来源：

CANCER LETTERS | 1999年 / 145卷 / 1-2期

关键词：

human leukemic cells; eicosapentaenoic acid; flow cytometry; cell cycle; apoptosis; Bcl-2;

D O I：

10.1016/S0304-3835(99)00224-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Dietary polyunsaturated fatty acids (PUFAs) have been reported as a potential group of natural products which modulate tumor cell growth. In present study, eicosapentaenoic acid (EPA) was found to inhibit proliferation of human leukemic HL-60 and K-562 cells in vitro. EPA arrested cell cycle progression at G0/G1 phase, and induced necrosis in both HL-60 and K-562 cells. However, EPA induced apoptosis only in HL-60 but not K-562 cells. Also, bcl-2 protein expression was downregulated in much greater extent than that of bar showing that depression of bcl-2 might be an important step during the EPA-induced apoptosis in HL-60 cells. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：17 / 27

页数：11

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