Enhancement of memory in cannabinoid CB1 receptor knock-out mice

被引：153

作者：

Reibaud, M

Obinu, MC

Ledent, C

Parmentier, M

Böhme, GA

Imperato, A

机构：

[1] Rhone Poulenc Rorer, Ctr Rech Vitry Alfortville, CNS Dept, F-94403 Vitry, France

[2] Free Univ Brussels, IRIBHN, B-1070 Brussels, Belgium

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1999年 / 379卷 / 01期

关键词：

cannabinoid receptor; cannabinoid CB1 knock-out mouse; memory;

D O I：

10.1016/S0014-2999(99)00496-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

We have used cannabinoid CB1 knock-out mice in a two-trial object recognition test to assess the role of cannabinoid CB1 receptors in memory. Cannabinoid CB1 knock-out mice are able to retain memory for at least 48 h after the first trial whereas the wild-type controls lose their capacity to retain memory after 24 h. These results suggest that endogenous cannabinoid CB1 receptors play a crucial role in the process of memory storage and retrieval. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：R1 / R2

页数：2

相关论文

共 8 条

[1] Scopolamine-induced deficits in a two-trial object recognition task in mice [J].

Dodart, JC ;

Mathis, C ;

Ungerer, A .

NEUROREPORT, 1997, 8 (05) :1173-1178

[2]

HEYSER CJ, 1993, J PHARMACOL EXP THER, V264, P194

[3] THE CANNABINOID RECEPTOR - BIOCHEMICAL, ANATOMICAL AND BEHAVIORAL CHARACTERIZATION [J].

HOWLETT, AC ;

BIDAUTRUSSELL, M ;

DEVANE, WA ;

MELVIN, LS ;

JOHNSON, MR ;

HERKENHAM, M .

TRENDS IN NEUROSCIENCES, 1990, 13 (10) :420-423

[4] Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice [J].

Ledent, C ;

Valverde, O ;

Cossu, C ;

Petitet, F ;

Aubert, LF ;

Beslot, F ;

Böhme, GA ;

Imperato, A ;

Pedrazzini, T ;

Roques, BP ;

Vassart, G ;

Fratta, W ;

Parmentier, M .

SCIENCE, 1999, 283 (5400) :401-404

[5] SYSTEMIC OR INTRAHIPPOCAMPAL CANNABINOID ADMINISTRATION IMPAIRS SPATIAL MEMORY IN RATS [J].

LICHTMAN, AH ;

DIMEN, KR ;

MARTIN, BR .

PSYCHOPHARMACOLOGY, 1995, 119 (03) :282-290

[6] STRUCTURE OF A CANNABINOID RECEPTOR AND FUNCTIONAL EXPRESSION OF THE CLONED CDNA [J].

MATSUDA, LA ;

LOLAIT, SJ ;

BROWNSTEIN, MJ ;

YOUNG, AC ;

BONNER, TI .

NATURE, 1990, 346 (6284) :561-564

[7] SHORT-TERM-MEMORY IMPAIRMENT IN CANNABIS-DEPENDENT ADOLESCENTS [J].

SCHWARTZ, RH ;

GRUENEWALD, PJ ;

KLITZNER, M ;

FEDIO, P .

AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1989, 143 (10) :1214-1219

[8] Improvement of memory in rodents by the selective CB1 cannabinoid receptor antagonist, SR 141716 [J].

Terranova, JP ;

Storme, JJ ;

Lafon, N ;

Perio, A ;

RinaldiCarmona, M ;

LeFur, G ;

Soubrie, P .

PSYCHOPHARMACOLOGY, 1996, 126 (02) :165-172