Copolymer 1: From basic research to clinical application

被引:56
作者
Teitelbaum, D [1 ]
Arnon, R [1 ]
Sela, M [1 ]
机构
[1] WEIZMANN INST SCI,DEPT IMMUNOL,IL-76100 REHOVOT,ISRAEL
关键词
experimental allergic encephalomyelitis; multiple sclerosis; Cop-1; Copaxone; autoimmunity;
D O I
10.1007/PL00000576
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Copolymer 1 (Cop-1) is a synthetic amino acid copolymer effective in suppression of experimental allergic encephalomyelitis (EAE). The suppressive effect of Cop-1 in EAE is a general phenomenon and is not restricted to a particular species, disease type or encephalitogen used for EAE induction. In phase III clinical trials Cop-1 was found to slow progression of disability and reduce the relapse rate in exacerbating-remitting multiple sclerosis (MS). In vivo and in vitro studies suggest that the mechanism for Cop-1 activity in EAE and MS involves the binding of Cop-1 to major histocompatibility complex class II molecules as an initial step. This binding results both in competition with myelin antigens for T-cell. activation and in induction of specific suppressor cells of the Th2 type. As an antigen-specific intervention, Cop-1 has the advantage of reduced probability of long-term damage to the immune system.
引用
收藏
页码:24 / 28
页数:5
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