How cytokines can influence the brain:: A role for chemokines?

被引：42

作者：

Guyon, Alice ^{[1
]}

Massa, Fabienne ^{[1
]}

Rovere, Carole ^{[1
]}

Nahon, Jean-Louis ^{[1
]}

机构：

[1] CNRS, Inst Pharmacol Mol & Cellulaire, UNSA, F-06560 Valbonne, France

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2008年 / 198卷 / 1-2期

关键词：

cytokines; chemokines; hypothalamus; inflammation; LPS; neurons;

D O I：

10.1016/j.jneuroim.2008.04.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Following inflammation or inflection, cytokines are released in the blood. Besides their effect on the immune system, cytokines can also act in the brain to modulate our behaviors, inducing for example anorexia when produced in large amount. This review focuses on our current knowledge on how cytokines can influence the brain and the behaviors through several possible pathways: modulating peripheral neurons which project to the brain through the vagus nerve. modulating the levels of hormones Such as leptin which can act to the brain through the humoral pathway and possibly acting directly in the brain, through the local production of cytokines and chemokines such as SDF-1 alpha/CXCL12. (C) 2008 Elsevier B.V All rights reserved.

引用

页码：46 / 55

页数：10

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