Initiation and processing of signals from the B cell antigen receptor

被引:362
作者
Reth, M [1 ]
Wienands, J [1 ]
机构
[1] MAX PLANCK INST IMMUNOBIOL, D-79108 FREIBURG, GERMANY
关键词
signal transduction; BCR; Ig-alpha; Ig-beta; transducer complex;
D O I
10.1146/annurev.immunol.15.1.453
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Current models of signal transduction from the antigen receptors on B and T cells still resemble equations with several unknown elements. Data from recent knockout experiments in cell lines and mice contradict the assumption that Src-family kinase and tyrosine kinases of the Syk/Zap-70 family are the transducer elements that set signaling from these receptors in motion. Using a functional definition of signaling elements, we discuss the current knowledge of signaling events from the BCR and suggest the existence of an as-yet-unknown BCR transducer complex.
引用
收藏
页码:453 / 479
页数:27
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