Structure and Biology of the Intervertebral Disk in Health and Disease

被引：180

作者：

Chan, Wilson C. W. ^{[1
]}

Sze, Kit Ling ^{[1
]}

Samartzis, Dino ^{[2
]}

Leung, Victor Y. L. ^{[3
]}

Chan, Danny ^{[1
]}

机构：

[1] Univ Hong Kong, Dept Biochem, LKS Fac Med, Pokfulam, Hong Kong, Peoples R China

[2] Univ Hong Kong, Dept Orthopaed & Traumatol, Div Spine Surg, Li Ka Shing Fac Med, Pokfulam, Hong Kong, Peoples R China

[3] Univ Hong Kong, Dept Orthopaed & Traumatol, Pokfulam, Hong Kong, Peoples R China

来源：

ORTHOPEDIC CLINICS OF NORTH AMERICA | 2011年 / 42卷 / 04期

关键词：

Intervertebral disk; Degeneration; Extracellular matrix; Development; Biology; LOW-BACK-PAIN; NUCLEUS PULPOSUS CELLS; ISSLS PRIZE WINNER; AGGRECAN GENE POLYMORPHISM; X COLLAGEN EXPRESSION; NECROSIS-FACTOR-ALPHA; SULFATE-RICH REGION; HUMAN LUMBAR DISCS; FAMILIAL PREDISPOSITION; EXTRACELLULAR-MATRIX;

D O I：

10.1016/j.ocl.2011.07.012

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

100224 [整形外科学];

摘要：

The intervertebral disks along the spine provide motion and protection against mechanical loading. The 3 structural components, nucleus pulposus, annulus fibrosus, and cartilage endplate, function as a synergistic unit, though each has its own role. The cells within each of these components have distinct origins in development and morphology, producing specific extracellular matrix proteins that are organized into unique architectures fit for intervertebral disk function. This article focuses on various aspects of intervertebral disk biology and disruptions that could lead to diseases such as intervertebral disk degeneration..

引用

页码：447 / +

页数：19

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