Exchange of viral promoter/enhancer elements with heterologous regulatory sequences generates targeted hybrid long terminal repeat vectors for gene therapy of melanoma

被引：59

作者：

Diaz, RM

Eisen, T

Hart, IR

Vile, RG

机构：

[1] HAMMERSMITH HOSP,IMPERIAL CANC RES FUND,LAB MOL THERAPY,ONCOL UNIT,LONDON W12 0NN,ENGLAND

[2] ST THOMAS HOSP,RAYNE INST,ICRF LAB,RICHARD DIMBLEBY DEPT CANC RES,LONDON SE1 7EH,ENGLAND

[3] MARIE CURIE RES INST,OXTED RH8 0TL,SURREY,ENGLAND

来源：

JOURNAL OF VIROLOGY | 1998年 / 72卷 / 01期

关键词：

D O I：

10.1128/JVI.72.1.789-795.1998

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

To generate transcriptionally targeted vectors, tissue-specific elements of the human tyrosinase promoter were exchanged with corresponding viral elements in the Moloney murine leukemia virus long terminal repeat (LTR). From these experiments, a vesicular stomatitis virus type G pseudotyped, hybrid LTR vector that contained three tyrosinase enhancer elements and gave high-level, tightly tissue-specific expression at high titers (3 x 10(7) CFU/ml) was constructed.

引用

收藏

页码：789 / 795

页数：7

相关论文

共 40 条

[1] MELANOCYTE-SPECIFIC EXPRESSION OF THE HUMAN TYROSINASE PROMOTER - ACTIVATION BY THE MICROPHTHALMIA GENE-PRODUCT AND ROLE OF THE INITIATOR [J].

BENTLEY, NJ ;

EISEN, T ;

GODING, CR .

MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (12) :7996-8006

[2] An adenovirus mutant that replicates selectively in p53-deficient human tumor cells [J].

Bischoff, JR ;

Kim, DH ;

Williams, A ;

Heise, C ;

Horn, S ;

Muna, M ;

Ng, L ;

Nye, JA ;

SampsonJohannes, A ;

Fattaey, A ;

McCormick, F .

SCIENCE, 1996, 274 (5286) :373-376

[3] IDENTIFICATION OF THE SL3-3 VIRUS ENHANCER CORE AS A T-LYMPHOMA CELL-SPECIFIC ELEMENT [J].

BORAL, AL ;

OKENQUIST, SA ;

LENZ, J .

JOURNAL OF VIROLOGY, 1989, 63 (01) :76-84

[4] VESICULAR STOMATITIS-VIRUS G GLYCOPROTEIN PSEUDOTYPED RETROVIRAL VECTORS - CONCENTRATION TO VERY HIGH-TITER AND EFFICIENT GENE-TRANSFER INTO MAMMALIAN AND NONMAMMALIAN CELLS [J].

BURNS, JC ;

FRIEDMANN, T ;

DRIEVER, W ;

BURRASCANO, M ;

YEE, JK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (17) :8033-8037

[5] HIGH-TITER PACKAGING CELLS PRODUCING RECOMBINANT RETROVIRUSES RESISTANT TO HUMAN SERUM [J].

COSSET, FL ;

TAKEUCHI, Y ;

BATTINI, JL ;

WEISS, RA ;

COLLINS, MKL .

JOURNAL OF VIROLOGY, 1995, 69 (12) :7430-7436

[6]

Cosset FL, 1996, GENE THER, V3, P946

[7] RETROVIRAL VECTORS CONTAINING CHIMERIC PROMOTER/ENHANCER ELEMENTS EXHIBIT CELL-TYPE-SPECIFIC GENE-EXPRESSION [J].

COUTURE, LA ;

MULLEN, CA ;

MORGAN, RA .

HUMAN GENE THERAPY, 1994, 5 (06) :667-677

[8] GENES WITH PROMOTERS IN RETROVIRUS VECTORS CAN BE INDEPENDENTLY SUPPRESSED BY AN EPIGENETIC MECHANISM [J].

EMERMAN, M ;

TEMIN, HM .

CELL, 1984, 39 (03) :459-467

[9] A RETROVIRAL VECTOR CONTAINING A MUSCLE-SPECIFIC ENHANCER DRIVES GENE-EXPRESSION ONLY IN DIFFERENTIATED MUSCLE-FIBERS [J].

FERRARI, G ;

SALVATORI, G ;

ROSSI, C ;

COSSU, G ;

MAVILIO, F .

HUMAN GENE THERAPY, 1995, 6 (06) :733-742

[10] SUBSTITUTION OF MURINE TRANSTHYRETIN (PREALBUMIN) REGULATORY SEQUENCES INTO THE MOLONEY MURINE LEUKEMIA-VIRUS LONG TERMINAL REPEAT YIELDS INFECTIOUS VIRUS WITH ALTERED BIOLOGICAL PROPERTIES [J].

FEUER, G ;

FAN, H .

JOURNAL OF VIROLOGY, 1990, 64 (12) :6130-6140

← 1 2 3 4 →