The Long-Term Stability of the Human Gut Microbiota

被引：1463

作者：

Faith, Jeremiah J. ^{[1
]}

Guruge, Janaki L. ^{[1
]}

Charbonneau, Mark ^{[1
]}

Subramanian, Sathish ^{[1
]}

Seedorf, Henning ^{[1
]}

Goodman, Andrew L. ^{[1
]}

Clemente, Jose C. ^{[3
]}

Knight, Rob ^{[3
,4
,5
]}

Heath, Andrew C. ^{[2
]}

Leibel, Rudolph L. ^{[6
,7
]}

Rosenbaum, Michael ^{[6
,7
]}

Gordon, Jeffrey I. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Ctr Genome Sci & Syst Biol, St Louis, MO 63108 USA

[2] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA

[3] Univ Colorado, Dept Chem & Biochem, Boulder, CO 80309 USA

[4] Univ Colorado, Biofrontiers Inst, Boulder, CO 80309 USA

[5] Univ Colorado, Howard Hughes Med Inst, Boulder, CO 80309 USA

[6] Columbia Univ Coll Phys & Surg, Div Mol Genet, Dept Pediat, New York, NY 10032 USA

[7] Columbia Univ Coll Phys & Surg, Div Mol Genet, Dept Med, New York, NY 10032 USA

来源：

SCIENCE | 2013年 / 341卷 / 6141期

关键词：

ENERGY-EXPENDITURE; RIBOSOMAL-RNA; TWINS; WEIGHT; DIVERSITY; BACTERIA; GENOME; OBESE; FLORA;

D O I：

10.1126/science.1237439

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A low-error 16S ribosomal RNA amplicon sequencing method, in combination with whole-genome sequencing of >500 cultured isolates, was used to characterize bacterial strain composition in the fecal microbiota of 37 U.S. adults sampled for up to 5 years. Microbiota stability followed a power-law function, which when extrapolated suggests that most strains in an individual are residents for decades. Shared strains were recovered from family members but not from unrelated individuals. Sampling of individuals who consumed a monotonous liquid diet for up to 32 weeks indicated that changes in strain composition were better predicted by changes in weight than by differences in sampling interval. This combination of stability and responsiveness to physiologic change confirms the potential of the gut microbiota as a diagnostic tool and therapeutic target.

引用

页码：44 / +

页数：2

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