Dendritic cells hold promise for immunotherapy

被引:128
作者
Girolomoni, G [1 ]
RicciardiCastagnoli, P [1 ]
机构
[1] UNIV MILAN,CNR,CTR CELLULAR & MOL PHARMACOL,I-20129 MILAN,ITALY
来源
IMMUNOLOGY TODAY | 1997年 / 18卷 / 03期
关键词
D O I
10.1016/S0167-5699(97)01030-X
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The possibility of generating large numbers of autologous dendritic cells (DCs) that can be used in the manipulation of the immune response against cancer and infections has tremendously boosted DC research. This and other issues of DC biology were discussed at a recent meeting*.
引用
收藏
页码:102 / 104
页数:3
相关论文
共 19 条
[1]   DENDRITIC CELLS GENERATED FROM PERIPHERAL-BLOOD TRANSFECTED WITH HUMAN TYROSINASE INDUCE SPECIFIC T-CELL ACTIVATION [J].
ALIJAGIC, S ;
MOLLER, P ;
ARTUC, M ;
JURGOVSKY, K ;
CZARNETZKI, BM ;
SCHADENDORF, D .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1995, 25 (11) :3100-3107
[2]   Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood [J].
Bender, A ;
Sapp, M ;
Schuler, G ;
Steinman, RM ;
Bhardwaj, N .
JOURNAL OF IMMUNOLOGICAL METHODS, 1996, 196 (02) :121-135
[3]   Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo [J].
Boczkowski, D ;
Nair, SK ;
Snyder, D ;
Gilboa, E .
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (02) :465-472
[4]   CD34(+) hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha [J].
Caux, C ;
Vanbervliet, B ;
Massacrier, C ;
DezutterDambuyant, C ;
deSaintVis, B ;
Jacquet, C ;
Yoneda, K ;
Imamura, S ;
Schmitt, D ;
Banchereau, J .
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (02) :695-706
[5]   Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation [J].
Cella, M ;
Scheidegger, D ;
PalmerLehmann, K ;
Lane, P ;
Lanzavecchia, A ;
Alber, G .
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (02) :747-752
[6]   DNA-based immunization by in vivo transfection of dendritic cells [J].
Condon, C ;
Watkins, SC ;
Celluzzi, CM ;
Thompson, K ;
Falo, LD .
NATURE MEDICINE, 1996, 2 (10) :1122-1128
[7]  
Henderson RA, 1996, CANCER RES, V56, P3763
[8]   Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells [J].
Heufler, C ;
Koch, F ;
Stanzl, U ;
Topar, G ;
Wysocka, M ;
Trinchieri, G ;
Enk, A ;
Steinman, RM ;
Romani, N ;
Schuler, G .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1996, 26 (03) :659-668
[9]   Vaccination of patients with B-cell lymphoma using autologous antigen-pulsed dendritic cells [J].
Hsu, FJ ;
Benike, C ;
Fagnoni, F ;
Liles, TM ;
Czerwinski, D ;
Taidi, B ;
Engleman, EG ;
Levy, R .
NATURE MEDICINE, 1996, 2 (01) :52-58
[10]  
Kitajima T, 1996, J IMMUNOL, V157, P2340