Efficient electrocatalytic oxidation and selective determination of isoniazid by Fe(tmphen)32+-exchanged Nafion®-modified electrode

被引：28

作者：

Azad, Uday Pratap ^{[1
]}

Ganesan, Vellaichamy ^{[1
]}

机构：

[1] Banaras Hindu Univ, Dept Chem, Fac Sci, Varanasi 221005, Uttar Pradesh, India

来源：

JOURNAL OF SOLID STATE ELECTROCHEMISTRY | 2012年 / 16卷 / 09期

关键词：

Nafion (R); Electrocatalysis; Isoniazid oxidation; Fe(tmphen)(3)(2+); GLASSY-CARBON ELECTRODE; FILM; PHARMACEUTICALS; PYRAZINAMIDE; CALIBRATION; PEROXIDASE; RIFAMPICIN; IRON(III); KINETICS; MEDIATOR;

D O I：

10.1007/s10008-012-1724-5

中图分类号：

O646 [电化学、电解、磁化学];

学科分类号：

070208 [无线电物理];

摘要：

Cyclic voltammetry and electrochemical impedance studies of Fe(tmphen) (3) (2+) (where tmphen = 3,4,7,8-tetramethyl-1,10-phenanthroline)-immobilized NafionA (R)-modified glassy carbon electrode (GC/Nf/Fe(tmphen) (3) (2+) ) are carried out in 0.1 M Na2SO4 solution. Nafion-Fe(tmphen) (3) (2+) complex exhibits efficient electrocatalytic oxidation of isoniazid. The linear double reciprocal plot of current and concentration of isoniazid shows a Michaelis-Menten-type catalytic process. The catalytic oxidation currents are proportional to the concentration of isoniazid and show a wide linear calibration range for the quantitative determination of isoniazid. Detection limit and sensitivity are found to be 13 mu M and 2.5 mu A mM(-1), respectively.

引用

页码：2907 / 2911

页数：5

共 29 条

[1]

Simultaneous polarographic determination of isoniazid and rifampicin by differential pulse polarography method and support vector regression [J].