Antibody Responses to Norovirus Genogroup GI.1 and GII.4 Proteases in Volunteers Administered Norwalk Virus

被引：16

作者：

Ajami, Nadim J. ^{[1
]}

Barry, Meagan A. ^{[2
]}

Carrillo, Berenice ^{[1
]}

Muhaxhiri, Zana ^{[3
]}

Neill, Frederick H. ^{[1
]}

Prasad, B. V. Venkataram ^{[1
,3
]}

Opekun, Antone R. ^{[4
,5
]}

Gilger, Mark A. ^{[4
]}

Graham, David Y. ^{[1
,5
]}

Atmar, Robert L. ^{[1
,2
,5
]}

Estes, Mary K. ^{[1
,2
,5
]}

机构：

[1] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Translat Biol & Mol Med, Houston, TX 77030 USA

[3] Baylor Coll Med, Dept Biochem & Mol Biol, Houston, TX 77030 USA

[4] Baylor Coll Med, Dept Pediat, Houston, TX 77030 USA

[5] Baylor Coll Med, Dept Med, Houston, TX 77030 USA

来源：

CLINICAL AND VACCINE IMMUNOLOGY | 2012年 / 19卷 / 12期

基金：

美国国家卫生研究院;

关键词：

CELLULAR IMMUNE-RESPONSES; HEPATITIS-A VIRUS; 3C PROTEINASE; INFECTION; GASTROENTERITIS; IMMUNOASSAY;

D O I：

10.1128/CVI.00411-12

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

An assay was developed to detect antibodies against two norovirus proteases among participants in a Norwalk virus (GI.1) challenge study. Prechallenge seroprevalence was lower against the protease from the homologous GI.1 virus than against protease from a heterologous GII.4 strain. Seroresponses were detected for 14 of 19 (74%) infected persons.

引用

页码：1980 / 1983

页数：4

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