Neutrophils and immunity: challenges and opportunities

被引：2295

作者：

Nathan, C

机构：

[1] Weill Cornell Med Coll, Dept Microbiol & Immunol, New York, NY 10021 USA

[2] Cornell Univ, Weill Grad Sch Med Sci, Program Immunol & Microbial Pathogenesis, New York, NY 10021 USA

[3] Cornell Univ, Weill Grad Sch Med Sci, Program Mol Biol, New York, NY 10021 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2006年 / 6卷 / 03期

关键词：

D O I：

10.1038/nri1785

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Scientists who study neutrophils often have backgrounds in cell biology, biochemistry, haematology, rheumatology or infectious disease. Paradoxically, immunologists seem to have a harder time incorporating these host-defence cells into the framework of their discipline. The recent literature discussed here indicates that it is appropriate for immunologists to take as much interest in neutrophils as in their lympho-haematopoietic cousins with smooth nuclei. Neutrophils inform and shape immune responses, contribute to the repair of tissue as well as its breakdown, use killing mechanisms that enrich our concepts of specificity, and offer exciting opportunities for the treatment of neoplastic, autoinflammatory and autoimmune disorders.

引用

页码：173 / 182

页数：10

共 97 条

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