Fatty acid composition of plasma phospholipids and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition

被引：121

作者：

Crowe, Francesca L. ^{[1
]}

Allen, Naomi E. ^{[1
]}

Appleby, Paul N. ^{[1
]}

Overvad, Kim ^{[2
]}

Aardestrup, Inge V. ^{[2
]}

Johnsen, Nina F. ^{[3
]}

Tjonneland, Anne ^{[3
]}

Linseisen, Jakob ^{[4
]}

Kaaks, Rudolf ^{[4
]}

Boeing, Heiner ^{[5
]}

Kroeger, Janine ^{[5
]}

Trichopoulou, Antonia ^{[6
]}

Zavitsanou, Assimina ^{[6
]}

Trichopoulos, Dimitrios ^{[7
]}

Sacerdote, Carlotta ^{[8
]}

Palli, Domenico ^{[9
]}

Tumino, Rosario ^{[10
]}

Agnoli, Claudia ^{[11
]}

Kiemeney, Lambertus A. ^{[12
]}

Bueno-de-Mesquita, H. Bas ^{[13
]}

Chirlaque, Maria-Dolores ^{[14
,15
]}

Ardanaz, Eva ^{[15
,16
]}

Larranaga, Nerea ^{[17
]}

Quiros, Jose R. ^{[18
]}

Sanchez, Maria-Jose ^{[15
,19
]}

Gonzalez, Carlos A. ^{[20
]}

Stattin, Paer ^{[22
]}

Hallmans, Goeran ^{[21
]}

Bingham, Sheila ^{[24
,25
]}

Khaw, Kay-Tee ^{[23
]}

Rinaldi, Sabina ^{[26
]}

Slimani, Nadia ^{[26
]}

Jenab, Mazda ^{[26
]}

Riboli, Elio ^{[27
]}

Key, Timothy J. ^{[1
]}

机构：

[1] Univ Oxford, Canc Epidemiol Unit, Oxford OX3 7LF, England

[2] Aarhus Univ Hosp, Aalborg Hosp, Dept Clin Epidemiol, Aalborg, Denmark

[3] Danish Canc Soc, Inst Canc Epidemiol, Copenhagen, Denmark

[4] German Canc Res Ctr, Div Canc Epidemiol, Unit Nutr Epidemiol, D-6900 Heidelberg, Germany

[5] German Inst Human Nutr, Potsdam, Germany

[6] Univ Athens, Sch Med, Dept Hyg & Epidemiol, GR-11527 Athens, Greece

[7] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[8] Epidemiol & Prevenz Oncol CPO Piemonte, Turin, Italy

[9] Sci Inst Tuscany, CSPO, Mol & Nutr Epidemiol Unit, Florence, Italy

[10] Azienda Ospedaliera Civile MP Arezzo, Canc Registry, Ragusa, Italy

[11] Ist Nazl Tumori, Fdn IRCCS, Nutr Epidemiol Unit, I-20133 Milan, Italy

[12] Radboud Univ Nijmegen, Med Ctr, NL-6525 ED Nijmegen, Netherlands

[13] Natl Inst Publ Hlth & Environm, NL-3720 BA Bilthoven, Netherlands

[14] Murcia Hlth Council, Dept Epidemiol, Murcia, Spain

[15] CIBERESP, Sao Paulo, Brazil

[16] Publ Hlth Inst Navarra, Pamplona, Spain

[17] Basque Govt, Publ Hlth Dept Gipuzkoa, Donostia San Sebastian, Spain

[18] Publ Hlth & Hlth Planning Directorate, Asturias, Spain

[19] Andalusian Sch Publ Hlth, Granada, Spain

[20] Catalan Inst Oncol, Canc Epidemiol Res Programme, Barcelona, Spain

[21] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

[22] Umea Univ, Dept Surg & Perioperat Sci Urol & Androl, Umea, Sweden

[23] Univ Cambridge, Dept Gerontol, Cambridge, England

[24] Univ Cambridge, MRC, Dunn Human Nutr Unit, Cambridge, England

[25] Univ Cambridge, MRC, Ctr Nutr Epidemiol Canc Prevent & Survival, Dept Publ Hlth & Primary Care, Cambridge, England

[26] IARC WHO, Nutr Hormones Grp, Lyon, France

[27] Univ London Imperial Coll Sci Technol & Med, London, England

来源：

AMERICAN JOURNAL OF CLINICAL NUTRITION | 2008年 / 88卷 / 05期

基金：

英国医学研究理事会;

关键词：

D O I：

10.3945/ajcn.2008.26369

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Background: Plausible biological mechanisms underlie possible associations between fatty acids in blood and risk of prostate cancer; epidemiologic evidence for an association, however, is inconsistent. Objective: The objectives were to assess the association between plasma phospholipid fatty acids and risk of total prostate cancer by stage and grade. Design: This was a nested case-control analysis of 962 men with a diagnosis of prostate cancer after a median follow-up time of 4.2 y and 1061 matched controls who were taking part in the European Prospective Investigation into Cancer and Nutrition. The fatty acid composition of plasma phospholipids was measured by gas chromatography, and the risk of prostate cancer was estimated by using conditional logistic regression with adjustment for lifestyle variables. Results: We found a positive association between palmitic acid and risk of total, localized, and low-grade prostate cancer. The risk of prostate cancer for men in the highest quintile compared with the lowest quintile of palmitic acid was 1.47 (95% CI: 0.97, 2.23; P for trend = 0.032). We found an inverse association between stearic acid and the risk of total, localized, and low-grade prostate cancer; men in the highest quintile of stearic acid had a relative risk of 0.77 (95% CI: 0.56, 1.06; P for trend = 0.03). There were significant positive associations between myristic, alpha-linolenic, and eicosapentaenoic acids and risk of high-grade prostate cancer. Conclusion: The associations between palmitic, stearic, myristic, alpha-linolenic, and eicosapentaenoic acids and prostate cancer risk may reflect differences in intake or metabolism of these fatty acids between the precancer cases and controls and should be explored further. Am J Clin Nutr 2008; 88: 1353-63.

引用

页码：1353 / 1363

页数：11

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