Comparative evaluation of the inhibitory activities of the novel penicillanic acid sulfone Ro 48-1220 against beta-lactamases that belong to groups 1, 2b, and 2be

被引：25

作者：

Tzouvelekis, LS ^{[1
]}

Gazouli, M ^{[1
]}

Prinarakis, EE ^{[1
]}

Tzelepi, E ^{[1
]}

Legakis, NJ ^{[1
]}

机构：

[1] UNIV ATHENS,SCH MED,DEPT MICROBIOL,GR-11521 ATHENS,GREECE

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 02期

关键词：

D O I：

10.1128/AAC.41.2.475

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The inhibitory activity of the penicillanic acid sulfone Ro 48-1220 against group 1, 2b, and 2be beta-lactamases was evaluated, Ro 48-1220 inhibited TEM and SHV enzymes as effectively as clavulanate and tazobactam. It also inhibited group 1 beta-lactamases at lower concentrations than tazobactam. Ro 48-1220, at a concentration of 4 mu g/ml, protected ceftriaxone and ceftazidime against strains producing group 1 and 2be beta-lactamases.

引用

页码：475 / 477

页数：3

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