Triterpenoid inhibitors of interleukin-1 secretion and tumour-promotion from Tripterygium wilfordii var. regelii

被引：56

作者：

Takaishi, Y

Wariishi, N

Tateishi, H

Kawazoe, K

Nakano, K

Ono, Y

Tokuda, H

Nishino, H

Iwashima, A

机构：

[1] OTSUKA PHARMACEUT CO LTD,TOKUSHIMA 77101,JAPAN

[2] KYOTO PREFECTURAL UNIV MED,DEPT BIOCHEM,KYOTO 602,JAPAN

来源：

PHYTOCHEMISTRY | 1997年 / 45卷 / 05期

关键词：

Tripterygium wilfordii; Celastraceae; triterpene; regeol; interleukin-1; antitumour-promoting activity;

D O I：

10.1016/S0031-9422(96)00859-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Three new triterpenoids, 2,3,22 beta-trihydroxy-21-oxo-24,29-nor-D:A-friedooleana-1,3,5(10)-triene, 2 alpha, 6 beta-dihydroxy-3-oxo-24-nor-D:A-friedooleana-4-ene-29-oic acid and 2,3,7-trihydroxy-6-oxo-24-nor-D:A-friedooleana-1,3,5(10), 7-tetraene-29-oic acid, named regeol A, B and C, and nine known triterpenoides were isolated from T. wilfordii var. regelii. Their structures were established on the basis of the chemical reactions and spectroscopic evidence. Isolated compounds and derivatives were observed to inhibit Epstein-Barr virus early antigen activation and showed potent inhibitory activities against interleukin-1 alpha and beta release from human peripheral mononuclear cells. (C) 1997 Elsevier Science Ltd. All rights reserved.

引用

页码：969 / 974

页数：6

共 23 条

[1]

GHEZZI P, 1988, J IMMUNOL, V140, P4238

[2]

CRYSTAL-STRUCTURE OF ORTHOSPHENIC ACID [J].