Solvent-free cyclocondensation of lactim ethers with anthranilic acid under microwave irradiation

被引：12

作者：

Cledera, P ^{[1
]}

Sánchez, JD ^{[1
]}

Caballero, E ^{[1
]}

Avendaño, C ^{[1
]}

Ramos, MT ^{[1
]}

Menéndez, JC ^{[1
]}

机构：

[1] Univ Complutense, Fac Farm, Dept Quim Organ & Farmaceut, E-28040 Madrid, Spain

来源：

SYNLETT | 2004年 / 05期

关键词：

microwave irradiation; iminoethers; cyclizations; antitumor agents; heterocycles;

D O I：

10.1055/s-2004-817784

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Microwave irradiation greatly improves the results of the cyclocondensation between anthranilic acid and lactim ethers derived from 2,5-piperazinediones in terms of reaction times, yields and stereocenter integrity, leading to pyrazino[2,1-b]quinazoline-3,6-diones. The microwave-assisted reaction was also much better than the thermal one when applied to a bis-lactim ether, leading to the corresponding pentacyclic pyrazino [2,1-b:5,4-b']diquinazoline-5,13-dione in excellent yield, and it also improved the preparation of compounds containing the ring system of the anti-MDR natural product N-acetylardeemin.

引用

页码：803 / 806

页数：4

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