Comorbidities Associated with Vitiligo: A Ten-Year Retrospective Study

被引:94
作者
Sheth, Vaneeta M. [1 ]
Guo, Ye [1 ]
Qureshi, Abrar A. [1 ]
机构
[1] Brigham & Womens Hosp, Dept Dermatol, Clin Res Program, Boston, MA 02115 USA
关键词
Vitiligo; Autoimmune; Comorbidity; Thyroid; Psoriasis; AUTOIMMUNE-DISEASES; GENERALIZED VITILIGO; COMBINATION; TACALCITOL; MUMBAI; INDIA;
D O I
10.1159/000354607
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100227 [皮肤病学];
摘要
Background: Vitiligo is a common disorder of depigmentation that has been associated with other autoimmune diseases. No recent large-scale data exist on the rates of comorbidities associated with vitiligo from the United States population. Objectives: To identify the prevalence of comorbidities as well as associated laboratory abnormalities in vitiligo patients. Methods: All medical records dating from January 1, 2000 to June 21, 2011 within the Research Patient Data Repository were evaluated retrospectively using a novel artificial intelligence-based computer program. A total of 3,280 patients carrying the diagnosis of vitiligo were identified using ICD-9 code 709.01. We randomly selected 300 patients and validated the diagnosis by manually reviewing their medical records. These results were used to create a model that was then applied to the larger set yielding 2,441 true vitiligo patients. 1,657 (68%) were diagnosed by dermatologists and 784 (32%) by non-dermatologists. We identified the prevalence of other comorbid autoimmune conditions by searching problem lists of vitiligo patients and collected laboratory data from the first available data point in the system for each patient. Results: Women were more frequently represented (57.6%) than men (42.4%). The majority of vitiligo patients were White/Caucasian (56.9%), followed by Hispanic/Latino (19.4%). 565 (23%) had one of the following comorbidities: 287 thyroid-related, 186 psoriasis, 72 rheumatoid arthritis, 59 alopecia areata, 55 inflammatory bowel disease, 53 systemic lupus and 20 type I diabetes mellitus. 41% had elevated anti-nuclear antibody levels. Almost half of the patients tested had elevated thyroid peroxidase antibodies. Over 50% of the patients tested had low or insufficient levels of 25-OH vitamin D. Conclusion: We found a high prevalence of comorbidities among individuals with vitiligo presenting to teaching hospitals in Boston, Mass. Comorbid autoimmune conditions were seen in 23% of vitiligo patients, thyroid disorders and psoriasis being the most common. Screening for these conditions, especially thyroid disorders, should be considered in vitiligo patients. (C) 2013 S. Karger AG, Basel
引用
收藏
页码:311 / 315
页数:5
相关论文
共 18 条
[1]
Epidemiology of vitiligo, associated autoimmune diseases and audiological abnormalities: Ankara study of 80 patients in Turkey [J].
Akay, B. N. ;
Bozkir, M. ;
Anadolu, Y. ;
Gullu, S. .
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2010, 24 (10) :1144-1150
[2]
Polyglandular autoimmune diseases in a dermatological clinical setting: vitiligo-associated autoimmune diseases [J].
Amerio, Paolo ;
Di Rollo, Daniela ;
Carbone, Angelo ;
Auriemma, Matteo ;
Marra, Maria Elena ;
De Remigis, Pierluigi ;
Feliciani, Claudio ;
Tracanna, Marco ;
Tulli, Antonio .
EUROPEAN JOURNAL OF DERMATOLOGY, 2010, 20 (03) :354-358
[3]
Cellular and molecular mechanisms involved in the action of vitamin D analogs targeting vitiligo depigmentation [J].
Birlea, S. A. ;
Costin, G. -E. ;
Norris, D. A. .
CURRENT DRUG TARGETS, 2008, 9 (04) :345-359
[4]
Evaluation of a generalizable approach to clinical information retrieval using the automated retrieval console (ARC) [J].
D'Avolio, Leonard W. ;
Nguyen, Thien M. ;
Farwell, Wildon R. ;
Chen, Yongming ;
Fitzmeyer, Felicia ;
Harris, Owen M. ;
Fiore, Louis D. .
JOURNAL OF THE AMERICAN MEDICAL INFORMATICS ASSOCIATION, 2010, 17 (04) :375-382
[5]
Polyglandular autoimmune syndromes: Immunogenetics and long-term follow-up [J].
Dittmar, M ;
Kahaly, GJ .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2003, 88 (07) :2983-2992
[6]
Statins and Prostate Cancer Diagnosis and Grade in a Veterans Population [J].
Farwell, Wildon R. ;
D'Avolio, Leonard W. ;
Scranton, Richard E. ;
Lawler, Elizabeth V. ;
Gaziano, J. Michael .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2011, 103 (11) :885-892
[7]
Narrowband ultraviolet B as monotherapy and in combination with topical calcipotriol in the treatment of generalized vitiligo [J].
Gamil, H. ;
Attwa, E. ;
Ghonemy, S. .
CLINICAL AND EXPERIMENTAL DERMATOLOGY, 2010, 35 (08) :919-921
[8]
Vitiligo Update [J].
Halder, Rebat M. ;
Chappell, Johnathan L. .
SEMINARS IN CUTANEOUS MEDICINE AND SURGERY, 2009, 28 (02) :86-92
[9]
Narita Tomohiko, 2011, Allergology International, V60, P505, DOI 10.2332/allergolint.11-OA-0303
[10]
Vitiligo epidemiological profile and the association with thyroid disease [J].
Nunes, Daniel Holthausen ;
Hademann Esser, Ligia Maria .
ANAIS BRASILEIROS DE DERMATOLOGIA, 2011, 86 (02) :241-248