Treatment for chronic heart failure in the elderly: current practice and problems

被引:75
作者
Abete, Pasquale [1 ]
Testa, Gianluca [1 ,2 ]
Della-Morte, David [3 ]
Gargiulo, Gaetano [1 ]
Galizia, Gianluigi [4 ]
de Santis, Domenico [1 ]
Magliocca, Antonio [1 ]
Basile, Claudia [1 ]
Cacciatore, Francesco [1 ,5 ]
机构
[1] Univ Naples Federico II, Cattedra Geriatria, Dipartimento Med Clin Sci Cardiovasc & Immunol, I-80131 Naples, Italy
[2] Univ Molise, Dipartimento Med & Sci Salute, Campobasso, Italy
[3] IRCCS, Dept Adv Biotechnol & Bioimaging, Rome, Italy
[4] IRCCS, Fdn Salvatore Maugeri, Ist Sci Veruno, Veruno, NO, Italy
[5] IRCCS, Fdn Salvatore Maugeri, Ist Sci Campoli Telese, Benevento, Italy
关键词
Chronic heart failure; Therapy; Comorbidity; Adherence; CONVERTING-ENZYME-INHIBITORS; VENTRICULAR SYSTOLIC FUNCTION; LONG-TERM MORTALITY; ASSOCIATION TASK-FORCE; RANDOMIZED-TRIAL; BETA-BLOCKERS; FOCUSED UPDATE; HEALTH-STATUS; RISK-FACTORS; PHARMACOLOGICAL-TREATMENT;
D O I
10.1007/s10741-012-9363-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Treatment for chronic heart failure (CHF) is strongly focused on evidence-based medicine. However, large trials are often far away from the "real world" of geriatric patients and their messages are poorly transferable to the clinical management of CHF elderly patients. Precipitating factors and especially non-cardiac comorbidity may decompensate CHF in the elderly. More importantly, drugs of first choice, such as angiotensin-converting enzyme inhibitors and beta-blockers, are still underused and effective drugs on diastolic dysfunction are not available. Poor adherence to therapy, especially for cognitive and depression disorders, worsens the management. Electrical therapy is indicated, but attention to the older age groups with reduced life expectancy has to be paid. Physical exercise, stem cells, gene delivery, and new devices are encouraging, but definitive results are still not available. Palliative care plays a key role to the end-stage of the disease. Follow-up of CHF elderly patient is very important but tele-medicine is the future. Finally, self-care management, caregiver training, and multidimensional team represent the critical point of the treatment for CHF elderly patients.
引用
收藏
页码:529 / 551
页数:23
相关论文
共 144 条
[1]   Effects of melatonin in isolated rat papillary muscle [J].
Abete, P ;
Bianco, S ;
Calabrese, C ;
Napoli, C ;
Cacciatore, F ;
Ferrara, N ;
Rengo, F .
FEBS LETTERS, 1997, 412 (01) :79-85
[2]   Role of Frailty in Patients With Cardiovascular Disease [J].
Afilalo, Jonathan ;
Karunananthan, Sathya ;
Eisenberg, Mark J. ;
Alexander, Karen P. ;
Bergman, Howard .
AMERICAN JOURNAL OF CARDIOLOGY, 2009, 103 (11) :1616-1621
[3]   Digoxin and reduction in mortality and hospitalization in heart failure:: a comprehensive post hoc analysis of the DIG trial [J].
Ahmed, A ;
Rich, MW ;
Love, TE ;
Lloyd-Jones, DM ;
Aban, IB ;
Colucci, WS ;
Adams, KF ;
Gheorghiade, M .
EUROPEAN HEART JOURNAL, 2006, 27 (02) :178-186
[4]   Prognostic importance of weight loss in chronic heart failure and the effect of treatment with angiotensin-converting-enzyme inhibitors: an observational study [J].
Anker, SD ;
Negassa, A ;
Coats, AJS ;
Afzal, R ;
Poole-Wilson, PA ;
Cohn, JN ;
Yusuf, S .
LANCET, 2003, 361 (9363) :1077-1083
[5]   Treatment of systolic and diastolic heart failure in the elderly [J].
Aronow, Wilbert S. .
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION, 2006, 7 (01) :29-36
[6]   Impact of Noncardiac Comorbidities on Morbidity and Mortality in a Predominantly Male Population With Heart Failure and Preserved Versus Reduced Ejection Fraction [J].
Ather, Sameer ;
Chan, Wenyaw ;
Bozkurt, Biykem ;
Aguilar, David ;
Ramasubbu, Kumudha ;
Zachariah, Amit A. ;
Wehrens, Xander H. T. ;
Deswal, Anita .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2012, 59 (11) :998-1005
[7]   Inflammatory and anti-inflammatory cytokines in chronic heart failure:: Potential therapeutic implications [J].
Aukrust, P ;
Gullestad, L ;
Ueland, T ;
Damås, JK ;
Yndestad, A .
ANNALS OF MEDICINE, 2005, 37 (02) :74-85
[8]   Stem cells for heart failure in the aging heart [J].
Ballard, Victoria L. T. .
HEART FAILURE REVIEWS, 2010, 15 (05) :447-456
[9]   Symptom distress and quality of life in patients with advanced congestive heart failure [J].
Blinderman, Craig D. ;
Hornel, Peter ;
Billings, J. Andrew ;
Portenoy, Russell K. ;
Tennstedt, Sharon L. .
JOURNAL OF PAIN AND SYMPTOM MANAGEMENT, 2008, 35 (06) :594-603
[10]  
Bonow RO, 2008, J AM COLL CARDIOL, V52, pE1, DOI [10.1016/j.hrthm.2008.04.014, 10.1016/j.jacc.2008.05.007]