Linking the epigenetic 'language' of covalent histone modifications to cancer

被引：268

作者：

Hake, SB ^{[1
]}

Xiao, A ^{[1
]}

Allis, CD ^{[1
]}

机构：

[1] Rockefeller Univ, Lab Chromatin Biol, New York, NY 10021 USA

来源：

BRITISH JOURNAL OF CANCER | 2004年 / 90卷 / 04期

关键词：

histones; chromatin; cancer; epigenetics;

D O I：

10.1038/sj.bjc.6601575

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Covalent modifications of histories, such as acetylation, methylation, and phosphorylation, and other epigenetic modulations of the chromatin, such as methylation of DNA and ATP-dependent chromatin reorganisation, can play a major part in the multistep process of carcinogenesis, with far-reaching implications for human biology and human health. This review focuses on how aberrant covalent histone modifications may contribute to the development of a variety of human cancers, and discusses the recent findings with regard to potential therapies.

引用

页码：761 / 769

页数：9

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