Novel tricyclic spiropiperidines. Synthesis and adrenergic activity of spiro[1,3-benzodioxolopiperidines] and spiro[1,3-benzodioxanepiperidines]

被引：5

作者：

Pujol, MD ^{[1
]}

Rosell, G ^{[1
]}

Guillaumet, G ^{[1
]}

机构：

[1] UNIV ORLEANS,INST CHIM ORGAN & ANALYT,F-45067 ORLEANS 2,FRANCE

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1996年 / 31卷 / 11期

关键词：

spiropiperidine; adrenergic antagonist; tertiary amine;

D O I：

10.1016/S0223-5234(97)89851-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of new series of spiropiperidines is reported. Some of these compounds showed interesting adrenergic activity. The biological activities of the new compounds were evaluated on-guinea pig atria (beta 1), guinea-pig trachea (beta 2) and rat vas deferens (alpha). Compounds 6a, 6c and 6f showed activity comparable to propranolol, in spite of being tertiary amines.

引用

页码：889 / 894

页数：6

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