Brain structural and cognitive correlates of clock drawing performance in Alzheimer's disease

被引:71
作者
Cahn-Weiner, DA
Sullivan, EV [1 ]
Shear, PK
Fama, R
Lim, KO
Yesavage, JA
Tinklenberg, JR
Pfefferbaum, A
机构
[1] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford, CA 94305 USA
[2] Vet Affairs Palo Alto Hlth Care Syst, Palo Alto, CA USA
[3] Univ Cincinnati, Dept Psychol, Cincinnati, OH 45221 USA
[4] SRI Int, Neuropsychiat Program, Menlo Pk, CA 94025 USA
关键词
Alzheimer's disease; clock drawing; neuroimaging;
D O I
10.1017/S1355617799566034
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The Clock Drawing Test (CDT) is widely used in the assessment of dementia and is known to be sensitive to the detection of deficits in neurodegenerative disorders such as Alzheimer's disease (AD). CDT performance is dependent not only on visuospatial and constructional abilities, but also on conceptual and executive functioning; therefore, it is likely to be mediated by multiple brain regions. The purpose of the present study was to identify component cognitive processes and regional cortical volumes that contribute to CDT performance in AD. in 29 patients with probable AD, CDT performance was significantly related to right-, but not left-hemisphere, regional gray matter volume. Specifically, CDT score correlated significantly with the right anterior and posterior superior temporal lobe volumes. CDT scores showed significant relationships with tests of semantic knowledge, executive function, and visuoconstruction, and receptive language. These. results suggest that in AD patients, CDT performance is attributable to impairment in multiple cognitive domains but is related specifically to regional volume loss of right temporal cortex.
引用
收藏
页码:502 / 509
页数:8
相关论文
共 35 条
[1]   Screening for dementia of the Alzheimer type in the community: The utility of the clock drawing test [J].
Cahn, DA ;
Salmon, DP ;
Monsch, AU ;
Butters, N ;
Wiederholt, WC ;
CoreyBloom, J ;
BarrettConnor, E .
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY, 1996, 11 (06) :529-539
[2]   AN ASSESSMENT OF THE SEMANTIC NETWORK IN PATIENTS WITH ALZHEIMERS-DISEASE [J].
CHAN, AS ;
BUTTERS, N ;
PAULSEN, JS ;
SALMON, DP ;
SWENSON, MR ;
MALONEY, LT .
JOURNAL OF COGNITIVE NEUROSCIENCE, 1993, 5 (02) :254-261
[3]   NORMATIVE DATA AND SCREENING POWER OF A SHORTENED VERSION OF TOKEN TEST [J].
DERENZI, E ;
FAGLIONI, P .
CORTEX, 1978, 14 (01) :41-49
[4]   Selective cortical and hippocampal volume correlates of Mattis Dementia Rating Scale in Alzheimer disease [J].
Fama, R ;
Sullivan, EV ;
Shear, PK ;
Marsh, L ;
Yesavage, JA ;
Tinklenberg, JR ;
Lim, KO ;
Pfefferbaum, A .
ARCHIVES OF NEUROLOGY, 1997, 54 (06) :719-728
[5]   MINI-MENTAL STATE - PRACTICAL METHOD FOR GRADING COGNITIVE STATE OF PATIENTS FOR CLINICIAN [J].
FOLSTEIN, MF ;
FOLSTEIN, SE ;
MCHUGH, PR .
JOURNAL OF PSYCHIATRIC RESEARCH, 1975, 12 (03) :189-198
[6]   NEUROPATHOLOGICAL BASIS FOR DRAWING DISABILITY (CONSTRUCTIONAL APRAXIA) IN ALZHEIMERS-DISEASE [J].
FORSTL, H ;
BURNS, A ;
LEVY, R ;
CAIRNS, N .
PSYCHOLOGICAL MEDICINE, 1993, 23 (03) :623-629
[7]  
Freedman M., 1994, Clock Drawing: A Neuropsychological Analysis
[8]  
GOODGLASS H, 1972, ASSESSMENT APHASIAS
[9]   Differentiating the roles of the hippocampal complex and the neocortex in long-term memory storage: Evidence from the study of semantic dementia and Alzheimer's disease [J].
Graham, KS ;
Hodges, JR .
NEUROPSYCHOLOGY, 1997, 11 (01) :77-89
[10]   SEMANTIC MEMORY IMPAIRMENT IN ALZHEIMERS-DISEASE - FAILURE OF ACCESS OR DEGRADED KNOWLEDGE [J].
HODGES, JR ;
SALMON, DP ;
BUTTERS, N .
NEUROPSYCHOLOGIA, 1992, 30 (04) :301-314