Distribution of serotypes, IS901 and a 40 kDa protein in Mycobacterium avium complex strains isolated from man and animals in Denmark

被引：11

作者：

Klausen, J ^{[1
]}

Giese, SB ^{[1
]}

Fuursted, K ^{[1
]}

Ahrens, P ^{[1
]}

机构：

[1] STATENS SERUM INST,DK-2300 COPENHAGEN,DENMARK

来源：

APMIS | 1997年 / 105卷 / 04期

关键词：

Mycobacterium avium; PCR; ELISA; serotyping;

D O I：

10.1111/j.1699-0463.1997.tb00569.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The aim of the present study was to characterize all strains of the Mycobacterium avium complex isolated in Denmark in 1993. A total of 141 M. avium complex strains (86 from man, 38 from animals, and 17 from peat) were analysed by serotyping, ELISA specific for a 40 kDa protein, and IS901-specific PCR. Serotype analysis showed that the most frequent serotypes among human strains were serotype 4 (27%) and serotype 6 (19%), which differs from an earlier survey where serotype 1 was most prevalent. The most frequent serotypes in animals were serotype 2 (53%) and serotype 6 (13%), whereas the most prevalent serotypes among strains isolated from peat were serotype 4 (29%) and serotype 9 (18%). There was a concurrent appearance of IS901 and p40 in all strains. Only M. avium complex strains isolated from animals, and belonging to serotype 1 or serotype 2, contained the IS901/p40 markers. The different distribution of serotypes of M. avium complex strains in animals and man, and the presence of IS901/p40 exclusively in animal strains, suggests that transmission of M. avium from animals to man is not of significance in Denmark.

引用

页码：277 / 282

页数：6

共 26 条

[1] 2 MARKERS, IS901-IS902 AND P40, IDENTIFIED BY PCR AND BY USING MONOCLONAL-ANTIBODIES IN MYCOBACTERIUM-AVIUM STRAINS [J].