Gin → Arg 191 polymorphism of paraoxonase and Parkinson's disease

被引：26

作者：

Akhmedova, S

Anisimov, S

Yakimovsky, A

Schwartz, E

机构：

[1] Russian Acad Sci, St Petersburg Inst Nucl Phys, Lab Human Mol Genet, Gatchina 188350, Russia

[2] St Petersburg State Univ, Dept Normal Physiol, St Petersburg, Russia

来源：

HUMAN HEREDITY | 1999年 / 49卷 / 03期

关键词：

Parkinson's disease; paraxonase; organophosphates;

D O I：

10.1159/000022868

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We investigated the Gln --> Arg 191 polymorphism-in paraoxonase (PON1) in St. Petersburg population, in three clinically differentiated groups of patients with Parkinson's disease (PD) and in the symptomatic tremor group. A new approach for Gln --> Arg 191 PON1 polymorphism genotyping is suggested. No significant differences in the groups studies as compared to the controls was observed.

引用

页码：178 / 180

页数：3

共 13 条

[1] ADKINS S, 1993, AM J HUM GENET, V52, P598
[2] How far are we in understanding the cause of Parkinson's disease?
BenShlomo, Y
[J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1996, 61 (01) : 4 - 16
[3] SERUM PARAOXONASE AND ITS INFLUENCE ON PARAOXON AND CHLORPYRIFOS-OXON TOXICITY IN RATS
COSTA, LG
MCDONALD, BE
MURPHY, SD
OMENN, GS
RICHTER, RJ
MOTULSKY, AG
FURLONG, CE
[J]. TOXICOLOGY AND APPLIED PHARMACOLOGY, 1990, 103 (01) : 66 - 76
[4] RISK-FACTORS IN YOUNG-ONSET PARKINSONS-DISEASE
GOLBE, LI
[J]. NEUROLOGY, 1993, 43 (09) : 1641 - 1643
[5] PARKINSONISM - ONSET PROGRESSION AND MORTALITY
HOEHN, MM
YAHR, MD
[J]. NEUROLOGY, 1967, 17 (05) : 427 - &
[6] RISK-FACTORS FOR PARKINSONS-DISEASE
HUBBLE, JP
CAO, T
HASSANEIN, RES
NEUBERGER, JS
KOLLER, WC
[J]. NEUROLOGY, 1993, 43 (09) : 1693 - 1697
[7] THE MOLECULAR-BASIS OF THE HUMAN SERUM PARAOXONASE ACTIVITY POLYMORPHISM
HUMBERT, R
ADLER, DA
DISTECHE, CM
HASSETT, C
OMIECINSKI, CJ
FURLONG, CE
[J]. NATURE GENETICS, 1993, 3 (01) : 73 - 76
[8] OXIDATIVE DAMAGE IN NEURODEGENERATIVE DISEASE
JENNER, P
[J]. LANCET, 1994, 344 (8925) : 796 - 798
[9] Environmental risk factors and Parkinson's disease: A case-control study in Taiwan
Liou, HH
Tsai, MC
Chen, CJ
Jeng, JS
Chang, YC
Chen, SY
Chen, RC
[J]. NEUROLOGY, 1997, 48 (06) : 1583 - 1588
[10] Dietary lipids and antioxidants in Parkinson's disease: A population-based, case-control study
Logroscino, G
Marder, K
Cote, L
Tang, MX
Shea, S
Mayeux, R
[J]. ANNALS OF NEUROLOGY, 1996, 39 (01) : 89 - 94

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