Penetration of rifampin through Staphylococcus epidermidis biofilms

被引：144

作者：

Zheng, ZL

Stewart, PS ^{[1
]}

机构：

[1] Montana State Univ, Ctr Biofilm Engn, Bozeman, MT 59717 USA

[2] Montana State Univ, Dept Chem Engn, Bozeman, MT 59717 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2002年 / 46卷 / 03期

关键词：

D O I：

10.1128/AAC.46.3.900-903.2002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Rifampin penetrated biofilms formed by Staphylococcus epidermidis but failed to effectively kill the bacteria. Penetration was demonstrated by a simple diffusion cell bioassay and by transmission electron microscopic observation of antibiotic-affected cells at the distal edge of the biofilm.

引用

收藏

页码：900 / 903

页数：4

相关论文

共 23 条

[1] Role of antibiotic penetration limitation in Klebsiella pneumoniae biofilm resistance to ampicillin and ciprofloxacin [J].

Anderl, JN ;

Franklin, MJ ;

Stewart, PS .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (07) :1818-1824

[2]

Andreoli-Pinto T J, 1999, Boll Chim Farm, V138, P19

[3] RESISTANCE OF BACTERIAL BIOFILMS TO ANTIBIOTICS - A GROWTH-RATE RELATED EFFECT [J].

BROWN, MRW ;

ALLISON, DG ;

GILBERT, P .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1988, 22 (06) :777-780

[4] Pacemaker infective endocarditis [J].

Cacoub, P ;

Leprince, P ;

Nataf, P ;

Hausfater, P ;

Dorent, R ;

Wechsler, B ;

Bors, V ;

Pavie, A ;

Piette, JC ;

Gandjbakhch, I .

AMERICAN JOURNAL OF CARDIOLOGY, 1998, 82 (04) :480-484

[5] Bacterial biofilms: A common cause of persistent infections [J].

Costerton, JW ;

Stewart, PS ;

Greenberg, EP .

SCIENCE, 1999, 284 (5418) :1318-1322

[6] VANCOMYCIN PENETRATION INTO BIOFILM COVERING INFECTED PROSTHESES AND EFFECT ON BACTERIA [J].

DAROUICHE, RO ;

DHIR, A ;

MILLER, AJ ;

LANDON, GC ;

RAAD, II ;

MUSHER, DM .

JOURNAL OF INFECTIOUS DISEASES, 1994, 170 (03) :720-723

[7] DIFFUSION OF RIFAMPIN AND VANCOMYCIN THROUGH A STAPHYLOCOCCUS-EPIDERMIDIS BIOFILM [J].

DUNNE, WM ;

MASON, EO ;

KAPLAN, SL .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1993, 37 (12) :2522-2526

[8]

FILICE G, 1986, CHEMIOTERAPIA, V5, P3

[9]

GRISTINA AG, 1985, SURGERY, V98, P12

[10]

Hyde JAJ, 1998, J HEART VALVE DIS, V7, P316