Bcl-2 transgenic mice with increased number of neurons have a greater learning capacity

Transgenic mice overexpressing Bcl-2 in their neurons have an increased number of neurons. To assess whether this increased number of neurons leads to increased learning capacity we have used the Hebb-Williams maze which provides a measure of learning suitable for the study of small animals. We have demonstrated that bcl-2 transgenic mice learn faster and are more accurate in this maze. They required fewer trials to complete the maze and committed fewer errors. The transgenic mice were also faster than the wildtype mice, in particular the older mice. Prior to learning both groups of mice behaved in a similar way. These results show that bcl-2 transgene expression enhances learning capacity in mice by increasing the number of neurons. (C) 1999 Elsevier Science B.V. All rights reserved.