Mechanisms of Gene Regulation by Fatty Acids

被引：251

作者：

Georgiadi, Anastasia ^{[1
]}

Kersten, Sander ^{[1
]}

机构：

[1] Wageningen Univ, Nutr Metab & Genom Grp, NL-6700 AP Wageningen, Netherlands

来源：

ADVANCES IN NUTRITION | 2012年 / 3卷 / 02期

关键词：

ACTIVATED-RECEPTOR-ALPHA; ELEMENT-BINDING PROTEIN-1; RETINOID-X-RECEPTOR; TOLL-LIKE RECEPTOR-4; PPAR-ALPHA; NUCLEAR RECEPTOR; COUPLED-RECEPTOR; LIGAND-BINDING; MOLECULAR RECOGNITION; DOCOSAHEXAENOIC ACID;

D O I：

10.3945/an.111.001602

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 [营养与食品卫生学];

摘要：

Consumption of specific dietary fatty acids has been shown to influence risk and progression of several chronic diseases, such as cardiovascular disease, obesity, cancer, and arthritis. In recent years, insights into the mechanisms underlying the biological effects of fatty acids have improved considerably and have provided the foundation for the emerging concept of fatty acid sensing, which can be interpreted as the property of fatty acids to influence biological processes by serving as signaling molecules. An important mechanism of fatty acid sensing is via stimulation or inhibition of DNA transcription. Here, we focus on fatty acid sensing via regulation of gene transcription and address the role of peroxisome proliferator-activated receptors, sterol regulatory element binding protein 1, Toll-like receptor 4, G protein-coupled receptors, and other putative mediators. Adv. Nutr. 3: 127-134, 2012.

引用

页码：127 / 134

页数：8

共 102 条

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High-density lipoprotein hydrolysis by endothelial lipase activates PPARα -: A candidate mechanism for high-density lipoprotein-mediated repression of leukocyte adhesion [J].