The amino acid substitutions Ser288Gly and Val320Ala convert the cortisol producing enzyme, CYP11B1, into an aldosterone producing enzyme

被引：69

作者：

Curnow, KM

Mulatero, P

EmericBlanchouin, N

AupetitFaisant, B

Corvol, P

Pascoe, L

机构：

[1] BAKER MED RES INST,PRAHRAN,VIC 3181,AUSTRALIA

[2] UNIV PARIS 06,CHU PITIE SALPETRIERE,SERV BIOCHIM,F-75634 PARIS 13,FRANCE

来源：

NATURE STRUCTURAL BIOLOGY | 1997年 / 4卷 / 01期

关键词：

D O I：

10.1038/nsb0197-32

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transfection studies with cDNAs encoding hybrids between the highly similar cytochrome P450 enzymes, CYP11B1 (steroid 11 beta-hydroxylase) and CYP11B2 (aldosterone synthase) have identified which amino acids determine the different activities of the enzymes.

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页码：32 / 35

页数：4

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