New indole derivatives with free radical scavenging activity from Agrocybe cylindracea

被引：54

作者：

Kim, WG

Lee, IK

Kim, JP

Ryoo, IJ

Koshino, H

Yoo, ID

机构：

[1] KIST,KOREA RES INST BIOSCI & BIOTECHNOL,TAEJON 305600,SOUTH KOREA

[2] RIKEN,WAKO,SAITAMA 35101,JAPAN

来源：

JOURNAL OF NATURAL PRODUCTS | 1997年 / 60卷 / 07期

关键词：

D O I：

10.1021/np970150w

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new indole derivatives were isolated as free radical scavengers from the MeOH extract of Agrocybe cylindracea. The structures of these compounds were determined to be 6-hydroxy-1H-indole-3-carboxaldehyde (1) and 6-hydroxy-1H-indole-3-acetamide (2) on the basis of spectroscopic studies. Compounds 1 and 2 inhibited lipid peroxidation in rat liver microsomes, with IC50 values of 4.1 and 3.9 mu g/mL, respectively.

引用

页码：721 / 723

页数：3

共 17 条

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[2]

HALLIWELL B, 1989, FREE RADICAL BIO MED, P416

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