Acylcarnitine analogues as topical, microbicidal spermicides.

被引：17

作者：

Savle, PS

Doncel, GF

Bryant, SD

Hubieki, MP

Robinette, RG

Gandour, RD ^{[1
]}

机构：

[1] Virginia Tech, Dept Chem, Blacksburg, VA 24061 USA

[2] Eastern Virginia Med Sch, Dept Obstet & Gynecol, CONRAD Program, Norfolk, VA 23507 USA

[3] Buckman Labs Int Inc, Memphis, TN 38108 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 17期

关键词：

D O I：

10.1016/S0960-894X(99)00423-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Acylcarnitine analogues, (+)-6-Carboxylatomethyl-2-alkyl-4,4-dimethylmorpholinium (Z-n, where n = the number of carbons in the alkyl chain), synthesized in multi-gram quantities show in vitro activities as spermicides, anti-HIV agents, and inhibitors of the growth of Candida albicans. Activity improves with increasing chain length. Compound Z-15 is a candidate for further study as a topical, microbicidal spermicide. (C) 1999 Elsevier Science Ltd. All rights reserved.

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收藏

页码：2545 / 2548

页数：4

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