Solution properties of amitriptyline and its partitioning into lipid bilayers

被引：23

作者：

Deo, N ^{[1
]}

Somasundaran, T ^{[1
]}

Somasundaran, P ^{[1
]}

机构：

[1] Columbia Univ, Langmuir Ctr Colloids & Interfaces, NSF IUCR Ctr Adv Studies Novel Surfactants, New York, NY 10027 USA

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2004年 / 34卷 / 03期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/j.colsurfb.2003.10.019

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 [生物物理学];

摘要：

Solution properties of a drug and its partitioning into lipid bilayers were studied for drug extraction using several different techniques, such as surface tension, zeta potential, ultra filtration and UV-Vis spectroscopy. From the surface tension study it was found that the presence of salt makes the drug molecules more surface-active. Zeta potential revealed the adsorption of the drug into the liposome bilayers to be governed mostly by electrostatic forces. The drug retention volume was expressed as a capacity factor, K, and that was normalized with respect to the amount of the immobilized phospholipids. The K-values for the positively charged drug on the liposomes decreased in the presence of phosphate buffer due to the presence of the oppositely charged ions. The above methods can thus be used to understand the mechanism of drug-membrane interaction and quantification of drug absorption into liposomes. © 2003 Elsevier B.V. All rights reserved.

引用

页码：155 / 159

页数：5

共 10 条

[1]

ALMONG S, 1992, IBI, V149, P345

[2]

The role of activated charcoal and gastric emptying in gastrointestinal decontamination: A state-of-the-art review [J].