MRI of laser-induced interstitial thermal injury in an in vivo animal liver model with histologic correlation

Laser-induced interstitial thermal therapy (LITT) is a preferred method of minimally invasive therapy, MRI is a noninvasive method by which to monitor the thermal effects of LITT, To properly control such effects, changes in MRI parameters during and after LITT should be correlated with changes in the tissue. T1-weighted fast spin echo (FSE) MRI (1 inage/10 seconds) at 1.5 T monitored LITT in vivo in rabbit liver (n = 6) using an interstitial bare delivery fiber (600-mu m diameter; 3.0 W; 1,064 nm; 150 seconds). During laser irradiation, MRI: signal intensity decreased around the fiber tip; after irradiation, this hypointensity proved reversible and permanent lesions were evident. The lesions had hyperintense margins that were brighter than surrounding normal tissue (P < .001); the tissue in these bright regions was mapped to tissue necrosis characterized by the presence of thermally damaged ghost red blood cells amid generally normal hepatocytes, T1-FSE identified the spatial extent of the LITT lesions.