Nuclear translocation of PDCD5 (TFAR19): an early signal for apoptosis?

被引：91

作者：

Chen, YY ^{[1
]}

Sun, RH ^{[1
]}

Han, WL ^{[1
]}

Zhang, YM ^{[1
]}

Song, QS ^{[1
]}

Di, CH ^{[1
]}

Ma, DL ^{[1
]}

机构：

[1] Peking Univ, Sch Basic Med Sci, Lab Med Immunol, Beijing 100083, Peoples R China

来源：

FEBS LETTERS | 2001年 / 509卷 / 02期

基金：

中国国家自然科学基金;

关键词：

TF-1 cell apoptosis related gene-19; programmed cell death 5; nuclear translocation; apoptosis;

D O I：

10.1016/S0014-5793(01)03062-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The programmed cell death 5 (PDCD5) protein is a novel protein related to regulation of cell apoptosis. In this report, we demonstrate that the level of PDCD5 protein expressed in cells undergoing apoptosis is significantly increased compared with normal cells, then the protein translocates rapidly from the cytoplasm to the nucleus of cells. The appearance of PDCD5 in the nuclei of apoptotic cells precedes the externalization of phosphatidylserine and fragmentation of chromosome DNA. This phenomenon is parallel to the loss of mitochondrial membrane potential, independent of the feature of apoptosis-inducing stimuli and also independent of the cell types and the apoptosis modality. In conclusion, the nuclear translocation of PDCD5 is a universal earlier event of the apoptotic process, and may be a novel early marker for apoptosis. (C) 2001 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：191 / 196

页数：6

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