Flavonoid metabolism: the interaction of metabolites and gut microbiota

被引：411

作者：

Murota, Kaeko ^{[1
]}

Nakamura, Yoshimasa ^{[2
]}

Uehara, Mariko ^{[3
]}

机构：

[1] Kindai Univ, Fac Sci & Technol, Dept Life Sci, Osaka, Japan

[2] Okayama Univ, Grad Sch Environm & Life Sci, Okayama, Japan

[3] Tokyo Univ Agr, Fac Appl Biosci, Dept Nutr Sci & Food Safety, Tokyo, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2018年 / 82卷 / 04期

基金：

日本学术振兴会;

关键词：

Flavonoid; phase II metabolism; ring-fission products; equol; microbial metabolism; EQUOL-PRODUCING BACTERIUM; ESTROGEN-RECEPTOR-ALPHA; CORONARY-HEART-DISEASE; BONE-MINERAL DENSITY; S-EQUOL; SOY ISOFLAVONES; 3,4-DIHYDROXYPHENYLACETIC ACID; GLUCURONIDE METABOLITES; QUERCETIN GLUCURONIDES; INTESTINAL MICROBIOTA;

D O I：

10.1080/09168451.2018.1444467

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Several dietary flavonoids exhibit anti-oxidative, anti-inflammatory, and anti-osteoporotic activities relevant to prevention of chronic diseases, including lifestyle-related diseases. Dietary flavonoids (glycoside forms) are enzymatically hydrolyzed and absorbed in the intestine, and are conjugated to their glucuronide/sulfate forms by phase II enzymes in epithelial cells and the liver. The intestinal microbiota plays an important role in the metabolism of flavonoids found in foods. Some specific products of bacterial transformation, such as ring-fission products and reduced metabolites, exhibit enhanced properties. Studies on the metabolism of flavonoids by the intestinal microbiota are crucial for understanding the role of these compounds and their impact on our health. This review focused on the metabolic pathways, bioavailability, and physiological role of flavonoids, especially metabolites of quercetin and isoflavone produced by the intestinal microbiota.

引用

页码：600 / 610

页数：11

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