New series of aryloxypropanolamines with both human β3-adrenoceptor agonistic activity and free radical scavenging properties

被引：15

作者：

Aubriot, S

Nicolle, E

Lattier, M

Morel, C

Cao, WH

Daniel, KW

Collins, S

Leclerc, G

Faure, P

机构：

[1] Univ Grenoble 1, UFR Pharm, CNRS, UMR 5063,Dept Pharmacochim Mol, F-38243 Meylan, France

[2] Univ Grenoble 1, UFR Pharm EA 2937, Lab Stress Cardiovasc & Pathol Associees, F-38700 La Tronche, France

[3] Duke Univ, Med Ctr, Div Biol Psychiat, Durham, NC 27710 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2002年 / 12卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(01)00716-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 13 novel hybrid molecules designed to possess both free radical scavenging activity and to stimulate the beta(3)-adrenoceptors in order to improve antidiabetic effect and to restore insulin sensitivity was synthesized and evaluated. Compounds were of quinolyl-, isoquinolyl-, pyridoindolyl- or carbazolyloxypropanolamine structure with a terminal amino group of benzopyranolyl-. di-tert-butylphenolyl- or methoxyindolyl- type. Some of the products possessed both the expected activities. (C) 2002 Elsevier Science Ltd. Ail rights reserved.

引用

页码：209 / 212

页数：4

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