Developing a physical model of the human cochlea using microfabrication methods

被引:50
作者
Wittbrodt, MJ
Steele, CR
Puria, S
机构
[1] Stanford Univ, Dept Mech Engn, Stanford, CA 94305 USA
[2] Stanford Univ, Dept Otolaryngol HNS, Stanford, CA 94305 USA
关键词
physical model of the human cochlea; microfabrication; basilar membrane; asymptotic method; polyimide; orthotropy;
D O I
10.1159/000090683
中图分类号
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号
100104 ; 100213 ;
摘要
Advances in micromachining technology have provided the opportunity to explore possibilities of creating life-sized physical models of the cochlea. The physical model of the cochlea consists of two fluid-filled channels separated by an elastic partition. The partition is micromachined from silicon and uses a 36-mm linearly tapered polyimide plate with a width of 100 mu m at the basal end and 500 mu m at the apex to represent the basilar membrane. Thicknesses from 1 to 5 mu m have been fabricated. Discrete aluminum fibers (1.5 mu m in width) are machined to create direction-dependent properties. A 0.5 x 0.5 mm opening represents the helicotrema. The fluid channels are machined from plexiglas using conventional machining methods. A magnet-coil system excites the fluid channel. Measurements on a model with thickness 4.75 mu m show a velocity gain of 4 and phase of 3.5 pi radians at a location 23 mm from the base. Mathematical modeling using a 3-D formulation confirm the general characteristics of the measured response. Copyright (C) 2006 S. Karger AG, Basel.
引用
收藏
页码:104 / 112
页数:9
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