Solid-phase synthesis of lysine-based cluster galactosides with high affinity for the asialoglycoprotein receptor

被引：51

作者：

Valentijn, ARPM

vanderMarel, GA

Sliedregt, LAJM

vanBerkel, TJC

Biessen, EAL

vanBoom, JH

机构：

[1] LEIDEN UNIV, LEIDEN INST CHEM, GORLAEUS LABS, NL-2300 RA LEIDEN, NETHERLANDS

[2] LEIDEN UNIV, LEIDEN AMSTERDAM CTR DRUG RES, SYLVIUS LABS, NL-2300 RA LEIDEN, NETHERLANDS

来源：

TETRAHEDRON | 1997年 / 53卷 / 02期

关键词：

D O I：

10.1016/S0040-4020(96)01018-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Structurally well defined di- and tri-antennary lysine-based galactose- and N-acetylgalactosamine-containing ligands for the hepatic asialoglycoprotein receptor (ASGP-R) could be assembled on a solid support, using a combined Fmoc/Alloc protecting group strategy for the amino functions of lysine. This methodology allowed easy introduction of spacers, the length of which could be readily accommodated for optimal binding to the ASGP-R. Copyright (C) 1996 Elsevier Science Ltd

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页码：759 / 770

页数：12

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