A hot story from comparative genomics: reverse gyrase is the only hyperthermophile-specific protein

被引：159

作者：

Forterre, P ^{[1
]}

机构：

[1] Univ Paris 11, CNRS, UMR 8621, Inst Microbiol & Genet, F-91405 Orsay, France

来源：

TRENDS IN GENETICS | 2002年 / 18卷 / 05期

关键词：

D O I：

10.1016/S0168-9525(02)02650-1

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

I have looked for proteins that are present in all hyperthermophile genomes, but absent from all mesophile or thermophile genomes by using the phylogenetic pattern search program of the COG database. Surprisingly, this search retrieved only one such hyperthermophile-specific protein: reverse gyrase. This result emphasizes the importance of reverse gyrase in the adaptation of life to very high temperatures, and strengthens the idea that evolution of this enzyme was crucial in the origin of hyperthermophiles.

引用

页码：236 / 238

页数：3

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