57 varieties: the human cytochromes P450

被引：199

作者：

Lewis, DFV ^{[1
]}

机构：

[1] Univ Surrey, Sch Biomed & Mol Sci, Guildford GU2 7XH, Surrey, England

来源：

PHARMACOGENOMICS | 2004年 / 5卷 / 03期

关键词：

cytochrome P450; human drug metabolism; molecular modeling;

D O I：

10.1517/phgs.5.3.305.29827

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The human cytochrome P450 (CYP) complement of heme-thiolate enzymes is reviewed. Of the 57 individual P450s characterized in Homo sapiens thus far, it is apparent that approximately one-half are associated with the metabolism of drugs and other xenobiotics, whereas the other half have endogenous functions in steroid, prostanoid, eicosanoid and fatty acid metabolism. This review covers the extent of enzyme functionality for the known human P450s, focusing primarily on their role in the Phase I metabolism of foreign compounds, which involves the CYP1, CYP2 and CYP3 families.

引用

页码：305 / 318

页数：14

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