Electrostatic zipper motif for DNA aggregation

被引：200

作者：

Kornyshev, AA

Leikin, S

机构：

[1] Univ Calif Santa Barbara, Inst Theoret Phys, Santa Barbara, CA 93106 USA

[2] Res Ctr Julich, D-52425 Julich, Germany

[3] NICHHD, Lab Phys & Struct Biol, NIH, Bethesda, MD 20892 USA

来源：

PHYSICAL REVIEW LETTERS | 1999年 / 82卷 / 20期

关键词：

D O I：

10.1103/PhysRevLett.82.4138

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

Counterion specificity of DNA condensation is rationalized from a theory of electrostatic interaction between helical molecules that accounts for different charge distribution patterns. an axial charge separation due to ion binding in helical grooves allows close approach of opposite charges along the DNA-DNA contact and forms an electrostatic "zipper" that "fastens" the molecules together. Predictions of the theory are in agreement with experimental data.

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收藏

页码：4138 / 4141

页数：4

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