MODOMICS: a database of RNA modification pathways-2013 update

被引：891

作者：

Machnicka, Magdalena A. ^{[1
]}

Milanowska, Kaja ^{[1
,2
]}

Oglou, Okan Osman ^{[3
]}

Purta, Elzbieta ^{[1
]}

Kurkowska, Malgorzata ^{[1
]}

Olchowik, Anna ^{[1
]}

Januszewski, Witold ^{[1
]}

Kalinowski, Sebastian ^{[2
]}

Dunin-Horkawicz, Stanislaw ^{[1
]}

Rother, Kristian M. ^{[1
,2
]}

Helm, Mark ^{[3
]}

Bujnicki, Janusz M. ^{[1
,2
]}

Grosjean, Henri ^{[4
]}

机构：

[1] Int Inst Mol & Cell Biol, Lab Bioinformat & Prot Engn, PL-02109 Warsaw, Poland

[2] Adam Mickiewicz Univ, Fac Biol, PL-61614 Poznan, Poland

[3] Johannes Gutenberg Univ Mainz, Inst Pharm & Biochem, D-55128 Mainz, Germany

[4] Univ Paris 11, CNRS, UPR 3404, Ctr Genet Mol,FRC 3115, F-91190 Gif Sur Yvette, France

来源：

NUCLEIC ACIDS RESEARCH | 2013年 / 41卷 / D1期

关键词：

IDENTIFICATION; RESISTANCE; ANTICODON; METHYLATION; RESOURCE; CYTIDINE; TOOLS;

D O I：

10.1093/nar/gks1007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

MODOMICS is a database of RNA modifications that provides comprehensive information concerning the chemical structures of modified ribonucleosides, their biosynthetic pathways, RNA-modifying enzymes and location of modified residues in RNA sequences. In the current database version, accessible at http://modomics.genesilico.pl, we included new features: a census of human and yeast snoRNAs involved in RNA-guided RNA modification, a new section covering the 5'-end capping process, and a catalogue of 'building blocks' for chemical synthesis of a large variety of modified nucleosides. The MODOMICS collections of RNA modifications, RNA-modifying enzymes and modified RNAs have been also updated. A number of newly identified modified ribonucleosides and more than one hundred functionally and structurally characterized proteins from various organisms have been added. In the RNA sequences section, snRNAs and snoRNAs with experimentally mapped modified nucleosides have been added and the current collection of rRNA and tRNA sequences has been substantially enlarged. To facilitate literature searches, each record in MODOMICS has been cross-referenced to other databases and to selected key publications. New options for database searching and querying have been implemented, including a BLAST search of protein sequences and a PARALIGN search of the collected nucleic acid sequences.

引用

页码：D262 / D267

页数：6

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